A0A8L2QK15 · A0A8L2QK15_RAT

  • Protein
    TGF-beta receptor type-2
  • Gene
    Tgfbr2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site275-283ATP (UniProtKB | ChEBI)
Binding site302ATP (UniProtKB | ChEBI)
Active site404Proton acceptor

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentexternal side of plasma membrane
Cellular Componenttransforming growth factor beta ligand-receptor complex
Molecular FunctionATP binding
Molecular Functionglycosaminoglycan binding
Molecular Functionkinase activator activity
Molecular Functionmetal ion binding
Molecular FunctionSMAD binding
Molecular Functiontransforming growth factor beta binding
Molecular Functiontransforming growth factor beta receptor activity, type II
Molecular Functiontype I transforming growth factor beta receptor binding
Biological Processaorta morphogenesis
Biological Processaortic valve morphogenesis
Biological Processbrain development
Biological Processbranching involved in blood vessel morphogenesis
Biological Processbronchus morphogenesis
Biological Processcardiac left ventricle morphogenesis
Biological Processembryonic cranial skeleton morphogenesis
Biological Processembryonic hemopoiesis
Biological Processendocardial cushion fusion
Biological Processepithelial to mesenchymal transition
Biological Processgastrulation
Biological Processgrowth plate cartilage chondrocyte growth
Biological Processheart looping
Biological Processin utero embryonic development
Biological Processinferior endocardial cushion morphogenesis
Biological ProcessLangerhans cell differentiation
Biological Processlens development in camera-type eye
Biological Processlens fiber cell apoptotic process
Biological Processlung lobe morphogenesis
Biological Processmammary gland morphogenesis
Biological Processmembranous septum morphogenesis
Biological ProcessmiRNA transport
Biological ProcessNotch signaling pathway
Biological Processoutflow tract septum morphogenesis
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of B cell tolerance induction
Biological Processpositive regulation of CD4-positive, alpha-beta T cell proliferation
Biological Processpositive regulation of epithelial cell migration
Biological Processpositive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
Biological Processpositive regulation of mesenchymal cell proliferation
Biological Processpositive regulation of NK T cell differentiation
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of SMAD protein signal transduction
Biological Processpositive regulation of T cell tolerance induction
Biological Processpositive regulation of tolerance induction to self antigen
Biological Processprotein phosphorylation
Biological Processregulation of gene expression
Biological Processregulation of stem cell differentiation
Biological Processregulation of stem cell proliferation
Biological Processresponse to cholesterol
Biological Processresponse to xenobiotic stimulus
Biological Processsecondary palate development
Biological ProcessSMAD protein signal transduction
Biological Processsmoothened signaling pathway
Biological Processtrachea formation
Biological Processtransforming growth factor beta receptor signaling pathway
Biological Processtricuspid valve morphogenesis
Biological Processvasculogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta receptor type-2
  • EC number
  • Short names
    TGFR-2
  • Alternative names
    • TGF-beta type II receptor
    • Transforming growth factor-beta receptor type II

Gene names

    • Name
      Tgfbr2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2QK15

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane raft
Membrane
; Single-pass type I membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_503543832724-592TGF-beta receptor type-2
Disulfide bond76↔109
Disulfide bond79↔96
Disulfide bond86↔92
Disulfide bond102↔126
Disulfide bond146↔161
Disulfide bond163↔168

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain269-571Protein kinase
Region571-592Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    592
  • Mass (Da)
    67,159
  • Last updated
    2022-08-03 v1
  • Checksum
    1D2171CE878D8A1F
MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSDVGMETQRDISIHLSCNRTVHPLKHFNSDLMAGDNSGAVKLPQLCKFCDVTLSTCDNQKSCMSNCSVTSICEKPQEVCVAVWRKNDKNITLETVCHDPKFTYHGFTLEDATSPTCVMKEKKRAGETFFMCSCNTEECNDYIIFNEEYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIAIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTEMGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPDRLSGRSCSQEKIPEDGSLNTTK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P38438TGFR2_RATTgfbr2567

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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