A0A8L2QEI7 · A0A8L2QEI7_RAT
- ProteinDual specificity mitogen-activated protein kinase kinase 2
- GeneMap2k2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids401 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 101 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | focal adhesion | |
Cellular Component | late endosome | |
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of early endosome to late endosome transport | |
Biological Process | regulation of Golgi inheritance | |
Biological Process | regulation of stress-activated MAPK cascade |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity mitogen-activated protein kinase kinase 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2QEI7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 72-370 | Protein kinase | |||
Region | 282-310 | Disordered | |||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length401
- Mass (Da)44,381
- Last updated2022-08-03 v1
- Checksum61B082B12472C349
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P36506 | MP2K2_RAT | Map2k2 | 400 | ||
A0A8I6AIR2 | A0A8I6AIR2_RAT | Map2k2 | 366 | ||
A0A8I6AW22 | A0A8I6AW22_RAT | Map2k2 | 376 | ||
A0A8I6A1A4 | A0A8I6A1A4_RAT | Map2k2 | 394 | ||
A0A8I5ZPN3 | A0A8I5ZPN3_RAT | Map2k2 | 422 |
Keywords
- Technical term