A0A8L2QCK9 · A0A8L2QCK9_RAT
- ProteinAcyltransferase
- GeneDgat2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids365 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol biosynthesis.
Lipid metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Cellular Component | mitochondrion | |
Cellular Component | perinuclear endoplasmic reticulum membrane | |
Molecular Function | 2-acylglycerol O-acyltransferase activity | |
Molecular Function | diacylglycerol O-acyltransferase activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | cellular response to oleic acid | |
Biological Process | cholesterol homeostasis | |
Biological Process | diacylglycerol biosynthetic process | |
Biological Process | fat pad development | |
Biological Process | fatty acid homeostasis | |
Biological Process | glycerol metabolic process | |
Biological Process | intracellular triglyceride homeostasis | |
Biological Process | lipid storage | |
Biological Process | long-chain fatty-acyl-CoA metabolic process | |
Biological Process | low-density lipoprotein particle clearance | |
Biological Process | monoacylglycerol biosynthetic process | |
Biological Process | triglyceride biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2QCK9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 73-94 | Helical | ||||
Sequence: VLQWVLSFLVLGVACSVILMYT |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)41,137
- Last updated2022-08-03 v1
- Checksum138816D50EA52A43
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5FVP8 | DGAT2_RAT | Dgat2 | 388 | ||
A0A0G2JUZ8 | A0A0G2JUZ8_RAT | Dgat2 | 358 | ||
A0A8I6A5T7 | A0A8I6A5T7_RAT | Dgat2 | 358 |
Keywords
- Technical term