A0A8L2Q3E0 · A0A8L2Q3E0_RAT
- Protein11-beta-hydroxysteroid dehydrogenase 1
- GeneHsd11b1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids328 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+This reaction proceeds in the forward direction.
- 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+This reaction proceeds in the forward direction.
- 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+This reaction proceeds in the forward direction.
- 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+This reaction proceeds in the forward direction.
- taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+This reaction proceeds in the forward and the backward directions.
- glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name11-beta-hydroxysteroid dehydrogenase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2Q3E0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-29 | Disordered | ||||
Sequence: MAGHPGGEDQAFPHSTQGPLSPGGTEAAE |
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length328
- Mass (Da)35,851
- Last updated2022-08-03 v1
- Checksum32943EC9DFAD7697
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P16232 | DHI1_RAT | Hsd11b1 | 288 | ||
Q6TUH9 | Q6TUH9_RAT | Hsd11b1 | 1104 | ||
A0A8I6GHA3 | A0A8I6GHA3_RAT | Hsd11b1 | 291 |
Keywords
- Technical term