A0A8L2Q3E0 · A0A8L2Q3E0_RAT

  • Protein
    11-beta-hydroxysteroid dehydrogenase 1
  • Gene
    Hsd11b1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

  • 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+
    This reaction proceeds in the forward direction.
  • taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.201 (UniProtKB | ENZYME | Rhea)
  • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:1.1.1.146 (UniProtKB | ENZYME | Rhea)
  • chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
  • glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    11-beta-hydroxysteroid dehydrogenase 1
  • EC number
  • Alternative names
    • 7-oxosteroid reductase
    • Corticosteroid 11-beta-dehydrogenase isozyme 1

Gene names

    • Name
      Hsd11b1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2Q3E0

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-29Disordered

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    35,851
  • Last updated
    2022-08-03 v1
  • Checksum
    32943EC9DFAD7697
MAGHPGGEDQAFPHSTQGPLSPGGTEAAELPEPGPCWTAVMKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P16232DHI1_RATHsd11b1288
Q6TUH9Q6TUH9_RATHsd11b11104
A0A8I6GHA3A0A8I6GHA3_RATHsd11b1291

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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