A0A8L2Q1Y2 · A0A8L2Q1Y2_RAT
- ProteinPeroxisome proliferator-activated receptor gamma coactivator 1-alpha
- GenePpargc1a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids723 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | PML body | |
Molecular Function | RNA binding | |
Molecular Function | transcription coregulator activity | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePeroxisome proliferator-activated receptor gamma coactivator 1-alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2Q1Y2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC. Interacts with FOXO1.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 25-65 | Disordered | |||
Region | 138-202 | Disordered | |||
Compositional bias | 147-166 | Basic and acidic residues | |||
Compositional bias | 167-202 | Polar residues | |||
Compositional bias | 215-231 | Polar residues | |||
Region | 215-277 | Disordered | |||
Compositional bias | 258-277 | Polar residues | |||
Compositional bias | 468-491 | Polar residues | |||
Region | 468-524 | Disordered | |||
Compositional bias | 501-524 | Polar residues | |||
Region | 538-596 | Disordered | |||
Compositional bias | 553-596 | Basic and acidic residues | |||
Domain | 602-678 | RRM | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length723
- Mass (Da)82,546
- Last updated2022-08-03 v1
- MD5 ChecksumF434BFB536F54019CAC422BD844EF0D0
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9QYK2 | PRGC1_RAT | Ppargc1a | 796 | ||
A0A8I6AWK0 | A0A8I6AWK0_RAT | Ppargc1a | 786 | ||
A0A8I5Y905 | A0A8I5Y905_RAT | Ppargc1a | 785 | ||
A0A8I6A531 | A0A8I6A531_RAT | Ppargc1a | 695 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 147-166 | Basic and acidic residues | |||
Compositional bias | 167-202 | Polar residues | |||
Compositional bias | 215-231 | Polar residues | |||
Compositional bias | 258-277 | Polar residues | |||
Compositional bias | 468-491 | Polar residues | |||
Compositional bias | 501-524 | Polar residues | |||
Compositional bias | 553-596 | Basic and acidic residues | |||
Keywords
- Technical term