A0A8K1ZRM2 · A0A8K1ZRM2_PLEAT

Function

Catalytic activity

  • (E)-hex-2-en-1-ol + NADP+ = (E)-hex-2-enal + H+ + NADPH
  • (E,E)-2,4-hexadien-1-ol + NADP+ = (E,E)-2,4-hexadienal + H+ + NADPH
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H+ + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP+
  • 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H+ + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 13-cis-retinol + NADP+ = 13-cis-retinal + H+ + NADPH
  • 9-cis-retinol + NADP+ = 9-cis-retinal + H+ + NADPH
  • NADP+ + prenol = 3-methyl-2-butenal + H+ + NADPH
  • NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin H2
  • a 4-hydroxynonen-1-ol + NADP+ = a 4-hydroxynonenal + H+ + NADPH
  • all-trans-retinol + NADP+ = all-trans-retinal + H+ + NADPH
    EC:1.1.1.300 (UniProtKB | ENZYME | Rhea)
  • an alditol + NADP+ = an aldose + H+ + NADPH
    EC:1.1.1.21 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site49Proton donor
Site78Lowers pKa of active site Tyr
Binding site111substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionoxidoreductase activity

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldo-keto reductase family 1 member B1
  • EC number
  • Alternative names
    • Aldose reductase

Gene names

    • Name
      AR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Stomiati > Osmeriformes > Plecoglossus

Accessions

  • Primary accession
    A0A8K1ZRM2

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-289NADP-dependent oxidoreductase

Sequence similarities

Belongs to the aldo/keto reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    35,461
  • Last updated
    2022-08-03 v1
  • Checksum
    9D5CCAC04EEC9E0F
MAKSVKLNTGAEMPIVGLGTWKSPPGKVTEAVKAAIAAGYRHIDGAFVYQNETEVGEGINAMVKDGVVKREELFVVSKLWCTFHEKALVKGACQKTLSDLRLDFLDLFLMHLPMGFQAGSELFPLDSEGLAITDGTNFLDTWEAMEELVDAGLVKAIGISNFNKDQIETLLNKPGLKYKPVTNQIECHPYLTQEKLISYCQSKGISVTAYSPLGSPDRPWAKPDDPSVLDDPNIKAIAQKYKKTSAQVLIRFQVQRNVIVIPKSITPQRIQENFQVFDFELTKEEMKIILGFNRSWRACTMHWGVKHKDYPFNTEF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN944400
EMBL· GenBank· DDBJ
UHH90925.1
EMBL· GenBank· DDBJ
mRNA
MN944401
EMBL· GenBank· DDBJ
UHH90926.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp