A0A8K1ER20 · A0A8K1ER20_CARTY

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Atyoidea > Atyidae > Caridina

Accessions

  • Primary accession
    A0A8K1ER20

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-102Helical
Transmembrane114-141Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_503541620420-153Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-153Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    153
  • Mass (Da)
    16,274
  • Last updated
    2022-08-03 v1
  • Checksum
    EC85E85E66A06082
VMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLSSGMVEKGVGTGWTVYPPLAGCTGHAGASVDLGIFSLHLAGISSILGAANFMSTVINMRTTGMLSDRMPLFVWSVFLTAVLLLLSLPVLAGAITMLLTDRNLNTSFFDP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue153

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZ093023
EMBL· GenBank· DDBJ
QUR41249.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ093024
EMBL· GenBank· DDBJ
QUR41250.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ093025
EMBL· GenBank· DDBJ
QUR41251.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ093026
EMBL· GenBank· DDBJ
QUR41252.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ093027
EMBL· GenBank· DDBJ
QUR41253.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ093029
EMBL· GenBank· DDBJ
QUR41255.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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