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A0A8K0XRJ4 · A0A8K0XRJ4_9AGAR

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BXZ70DRAFT_929334

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KKN 215
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Pleurotineae > Stephanosporaceae > Cristinia

Accessions

  • Primary accession
    A0A8K0XRJ4

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane54-76Helical
Transmembrane96-118Helical
Transmembrane125-146Helical
Transmembrane152-170Helical
Transmembrane182-199Helical
Transmembrane219-239Helical
Transmembrane302-322Helical
Transmembrane342-362Helical
Transmembrane369-390Helical
Transmembrane477-499Helical
Transmembrane610-632Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-31Disordered
Region556-576Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    645
  • Mass (Da)
    69,991
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    70E3804830F2C9EA506F4E9D3C428187
MPREGSAQTHSVHSEHYQPLPDEETSVDDDDSVSQLEELRIVAHVKRPPPVRAYLVRALALLCACSLSIGSHYASYILGPLKSRLSREMGTDNTEFSLLISAFSLNSTWTPLVGGILASRLGTTMTSILATGVVFLGQLFLLIGNLVGSVRLMAFGMFVFGFGVSPLAVVQETIIVRFFKSHGLGISLALGLVAGKGASFVSARTSYPLSQHFGPHAPFYVATGLAGLSFCINIVYLLASKWLVLGAGAEWEASELHAEAQTQRAEHIRSGSVQSLTEAEALNAVAEKRMVKFKDITKLGDVFWAYMGLNVFCGMIWAPWTHLAANIIQRRFSMSESKSSEIASYILAGSVFLYPITGWAVDALKHRGIVLRLLATSSILTLLCYVWMALPSDFTQTPIPGVIAFGLGHGFSPLLLVCIVPEIVPLKYVSTTLGAHKALEQTGSTIFQTMAGLVLDVKSKKPSVESVNNGDDTDVQYLLNTFIVINVLQFIAIVTLAHFDRKRKQILARRASALLSPPVEESSDSEEPVAGPAKEPIVPAIADAGRGGTIRSIRSLRRPSTSSTEQHIPLLRSASQSSSARSSRYLIPGSSPSAAVSLKFSKGELRRGRIFVVLSGCMILFAWVLFMGTAWYRLRSKEERGHAMH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEVFJ010000009
EMBL· GenBank· DDBJ
KAH8102645.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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