A0A8K0WU41 · A0A8K0WU41_9HYPO
- Proteintripeptidyl-peptidase II
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1468 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
Catalytic activity
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 268 | Charge relay system | ||||
Sequence: E | ||||||
Active site | 272 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 489 | Charge relay system | ||||
Sequence: S | ||||||
Binding site | 532 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 533 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 555 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 557 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ binding | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | transferase activity | |
Molecular Function | tripeptidyl-peptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametripeptidyl-peptidase II
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Stachybotryaceae > Stachybotrys
Accessions
- Primary accessionA0A8K0WU41
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MSSTVLGQIVALAGLGFGAASA | ||||||
Chain | PRO_5035476862 | 23-1468 | tripeptidyl-peptidase II | |||
Sequence: VRQPSSFIPGGWQALDDQVKPSEPLRLSIALRQPGIGQVWGRIGSREHLSRGEVAALRAPDEQDADDVMRWLATHGITNAKVQKDWIHVQTTVGQAEPLLQMKMQYYAFEDKEPILRTREYSIPDSLSQAIQFVHPIDNFITPKRELSATSPPLEEGGLDVREAACRTGTSPNCIRELYNFNYTGSGPSDIRFGVAGFLEEWANYQDAHQFLQMAAPNIASTSYNFSVELVNGGENSQNVRYAGLEAALDIDYAMALGYPAKVTYYSTGGRGVELGDDGEPLEGDLVDNEPYLELLEYLLDKDDSELPHVLSVSYADDELSVPRHYAERVCDLFGLLTSRGTTILGGSGDGGARGARNSTCRTNDGTNQEVAMAVFPATCPWVTAVGAVSNAFDPPQGATYSGGGFSQYFARERWQDAAVQGYVKALGSHMGSKYNASMRATPDISAIGSQFMVVIASQITRLQGTSASTPVIAAMMVQINDARVRQGKKPLGWINGLLYSDEVRKTLRDVTVGESEPCPFSGGEAGWPAKEGYDAITGLGVPGDFEALMQVLSAWGAAVLNASSRWRATGLSQPVSKLRRARTMPTQHVEPASDDLLQQIADSLLKARKVVVVTGAGISTNSGIPDFRSENGLYSLIQAQFDAAARQARPVESADSDKDEASFQEPPAKRRSTDVKREPPSEESQDDSEACADGTVVNSNHEANEEVDGTSPPSPNAQLLSTPQPKFKHPSPTTSPLSSPPPEDFILTPRGFQDSTRSRLYKTTIPLSSSPLSSPPPGLFDPYPPSSPSDSSTTQNSTSPSELDDSPPSSNNFSSQSSTKSTLPNMKGKDLFDASIWSDPLRTSVFYTFATTLRQKVKEVTPTPSHHFISHLRDRGKLVRCYTQNIDQIEEKVGLSTCLTAGPGSRGRFSRRSTANTSQLNKMVEEASDSSKSQTDASQSQDTEDSQPKTNSEGDTTEQEKHEPPAIKREPSRTGVECVFLHGSLEQLRCFLCGRVCSWDEAGRQEETLSGQQPECPHCAGATARREERGKRALGVGKLRPDIVLYGEDHPNSHLISPIVTHDLALQPDMLLILGTSLRVHGLKVMVREFAKAVHNRAGKVVFVNFTKPPESAWGDIIDYWIQWDCDAWVDNLQGRIPKLWQALEPPKPKKKRDSAGKSDIETKKPPAANPVAQRDTKATGAYWSLKIINELHRITGTPPLPSQPRRASLPTTETTSEPRPQPPKAERTKPKRPRKSAPGALEKQQKPSTLNPNHGRPRRQQDTADSVPATPVVKKELPSIPISSILDSVKSNPRVRKRKMIDGEEVVMPKIGRRRTANSTPAPTFPPPLPELKLAPLNPQPASPSSPYGRPEPLEPQSPPPGPPLASISANPRNWLHDAFAMTGSPIQWPEHPMTARPLRLLPAQEEDKSQAAARALAELRDSWNVRRPPQDQRASMPINVKAM |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 191-577 | Peptidase S53 | ||||
Sequence: GTSPNCIRELYNFNYTGSGPSDIRFGVAGFLEEWANYQDAHQFLQMAAPNIASTSYNFSVELVNGGENSQNVRYAGLEAALDIDYAMALGYPAKVTYYSTGGRGVELGDDGEPLEGDLVDNEPYLELLEYLLDKDDSELPHVLSVSYADDELSVPRHYAERVCDLFGLLTSRGTTILGGSGDGGARGARNSTCRTNDGTNQEVAMAVFPATCPWVTAVGAVSNAFDPPQGATYSGGGFSQYFARERWQDAAVQGYVKALGSHMGSKYNASMRATPDISAIGSQFMVVIASQITRLQGTSASTPVIAAMMVQINDARVRQGKKPLGWINGLLYSDEVRKTLRDVTVGESEPCPFSGGEAGWPAKEGYDAITGLGVPGDFEALMQVLSA | ||||||
Domain | 613-1171 | Deacetylase sirtuin-type | ||||
Sequence: EPASDDLLQQIADSLLKARKVVVVTGAGISTNSGIPDFRSENGLYSLIQAQFDAAARQARPVESADSDKDEASFQEPPAKRRSTDVKREPPSEESQDDSEACADGTVVNSNHEANEEVDGTSPPSPNAQLLSTPQPKFKHPSPTTSPLSSPPPEDFILTPRGFQDSTRSRLYKTTIPLSSSPLSSPPPGLFDPYPPSSPSDSSTTQNSTSPSELDDSPPSSNNFSSQSSTKSTLPNMKGKDLFDASIWSDPLRTSVFYTFATTLRQKVKEVTPTPSHHFISHLRDRGKLVRCYTQNIDQIEEKVGLSTCLTAGPGSRGRFSRRSTANTSQLNKMVEEASDSSKSQTDASQSQDTEDSQPKTNSEGDTTEQEKHEPPAIKREPSRTGVECVFLHGSLEQLRCFLCGRVCSWDEAGRQEETLSGQQPECPHCAGATARREERGKRALGVGKLRPDIVLYGEDHPNSHLISPIVTHDLALQPDMLLILGTSLRVHGLKVMVREFAKAVHNRAGKVVFVNFTKPPESAWGDIIDYWIQWDCDAWVDNLQGRIPKLWQALEPPK | ||||||
Region | 670-847 | Disordered | ||||
Sequence: QARPVESADSDKDEASFQEPPAKRRSTDVKREPPSEESQDDSEACADGTVVNSNHEANEEVDGTSPPSPNAQLLSTPQPKFKHPSPTTSPLSSPPPEDFILTPRGFQDSTRSRLYKTTIPLSSSPLSSPPPGLFDPYPPSSPSDSSTTQNSTSPSELDDSPPSSNNFSSQSSTKSTLP | ||||||
Compositional bias | 674-707 | Basic and acidic residues | ||||
Sequence: VESADSDKDEASFQEPPAKRRSTDVKREPPSEES | ||||||
Compositional bias | 714-756 | Polar residues | ||||
Sequence: CADGTVVNSNHEANEEVDGTSPPSPNAQLLSTPQPKFKHPSPT | ||||||
Compositional bias | 774-792 | Polar residues | ||||
Sequence: GFQDSTRSRLYKTTIPLSS | ||||||
Compositional bias | 793-807 | Pro residues | ||||
Sequence: SPLSSPPPGLFDPYP | ||||||
Compositional bias | 808-847 | Polar residues | ||||
Sequence: PSSPSDSSTTQNSTSPSELDDSPPSSNNFSSQSSTKSTLP | ||||||
Region | 929-993 | Disordered | ||||
Sequence: RGRFSRRSTANTSQLNKMVEEASDSSKSQTDASQSQDTEDSQPKTNSEGDTTEQEKHEPPAIKRE | ||||||
Compositional bias | 930-970 | Polar residues | ||||
Sequence: GRFSRRSTANTSQLNKMVEEASDSSKSQTDASQSQDTEDSQ | ||||||
Compositional bias | 971-993 | Basic and acidic residues | ||||
Sequence: PKTNSEGDTTEQEKHEPPAIKRE | ||||||
Region | 1167-1199 | Disordered | ||||
Sequence: LEPPKPKKKRDSAGKSDIETKKPPAANPVAQRD | ||||||
Compositional bias | 1168-1184 | Basic and acidic residues | ||||
Sequence: EPPKPKKKRDSAGKSDI | ||||||
Region | 1218-1440 | Disordered | ||||
Sequence: ITGTPPLPSQPRRASLPTTETTSEPRPQPPKAERTKPKRPRKSAPGALEKQQKPSTLNPNHGRPRRQQDTADSVPATPVVKKELPSIPISSILDSVKSNPRVRKRKMIDGEEVVMPKIGRRRTANSTPAPTFPPPLPELKLAPLNPQPASPSSPYGRPEPLEPQSPPPGPPLASISANPRNWLHDAFAMTGSPIQWPEHPMTARPLRLLPAQEEDKSQAAARA | ||||||
Compositional bias | 1244-1263 | Basic and acidic residues | ||||
Sequence: PQPPKAERTKPKRPRKSAPG | ||||||
Compositional bias | 1266-1291 | Polar residues | ||||
Sequence: EKQQKPSTLNPNHGRPRRQQDTADSV | ||||||
Compositional bias | 1315-1335 | Basic and acidic residues | ||||
Sequence: SNPRVRKRKMIDGEEVVMPKI | ||||||
Compositional bias | 1345-1391 | Pro residues | ||||
Sequence: PAPTFPPPLPELKLAPLNPQPASPSSPYGRPEPLEPQSPPPGPPLAS |
Sequence similarities
Belongs to the sirtuin family. Class I subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,468
- Mass (Da)160,038
- Last updated2022-08-03 v1
- ChecksumD999594B4A1DFFFF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 674-707 | Basic and acidic residues | ||||
Sequence: VESADSDKDEASFQEPPAKRRSTDVKREPPSEES | ||||||
Compositional bias | 714-756 | Polar residues | ||||
Sequence: CADGTVVNSNHEANEEVDGTSPPSPNAQLLSTPQPKFKHPSPT | ||||||
Compositional bias | 774-792 | Polar residues | ||||
Sequence: GFQDSTRSRLYKTTIPLSS | ||||||
Compositional bias | 793-807 | Pro residues | ||||
Sequence: SPLSSPPPGLFDPYP | ||||||
Compositional bias | 808-847 | Polar residues | ||||
Sequence: PSSPSDSSTTQNSTSPSELDDSPPSSNNFSSQSSTKSTLP | ||||||
Compositional bias | 930-970 | Polar residues | ||||
Sequence: GRFSRRSTANTSQLNKMVEEASDSSKSQTDASQSQDTEDSQ | ||||||
Compositional bias | 971-993 | Basic and acidic residues | ||||
Sequence: PKTNSEGDTTEQEKHEPPAIKRE | ||||||
Compositional bias | 1168-1184 | Basic and acidic residues | ||||
Sequence: EPPKPKKKRDSAGKSDI | ||||||
Compositional bias | 1244-1263 | Basic and acidic residues | ||||
Sequence: PQPPKAERTKPKRPRKSAPG | ||||||
Compositional bias | 1266-1291 | Polar residues | ||||
Sequence: EKQQKPSTLNPNHGRPRRQQDTADSV | ||||||
Compositional bias | 1315-1335 | Basic and acidic residues | ||||
Sequence: SNPRVRKRKMIDGEEVVMPKI | ||||||
Compositional bias | 1345-1391 | Pro residues | ||||
Sequence: PAPTFPPPLPELKLAPLNPQPASPSSPYGRPEPLEPQSPPPGPPLAS |
Keywords
- Technical term