A0A8K0P8H1 · A0A8K0P8H1_LADFU
- Proteinprostaglandin-endoperoxide synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids647 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | neuron projection | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
Molecular Function | peroxidase activity | |
Molecular Function | prostaglandin-endoperoxide synthase activity | |
Biological Process | cyclooxygenase pathway | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameprostaglandin-endoperoxide synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Odonata > Epiprocta > Anisoptera > Libellulidae > Ladona
Accessions
- Primary accessionA0A8K0P8H1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: IPICATFIFFFISGVVLE | ||||||
Chain | PRO_5035431919 | 19-647 | prostaglandin-endoperoxide synthase | |||
Sequence: ETTTASGENFTFNPCCSFPCHHSGVCIQISSHTYECDCTNTGYYGKDCNKPYFRKKFDEMFTFPFNYKDYYLCGEPLVWSIVNHIEDLHGEVLKLFYSAGGSESKINPARYNSKYDYITADSHFDFSSIARILPQVPINCPTPMGVLGPKVYPDEGEIFHKLFLRRRFKPDPHGTNLLFLAFLEHLTFTLIKRDEPDGYNFSKFPFEFDSDHIYGKDDETRRELRTLQGGRLKTSSINDEIYPPLQLSSVVVPQTQSEKSLEEDPCNTLLELGLGDTGLINATVKGCLADVDMEYPPETKGLRFALAHPKLAKTPFLLMLSTIWIREHNRVAHLIAIEHPDWDDERLYQVTRLIITGELIHITVTDFLKQLTQYNLDIVWNPNVLDEKIMAERISIEIQQLQHWHAMIPDCIKIGNSTLNYTETFYNNEILTKFGVDYIIDILSRDTAGKVTYRNYAESMRKTVIDTILKGRKNRLQSFNSYRKNYGLEPYRSMFELCGDEKLAASLDKFYGDINAIEFFVGLAVETHRCSVFPPTQMAIGGPYIMKSIFSSPLNSPQWWKSSTFGGELGFKIVSEVTLRGLFCQNMKNRCKGEEYVSFHIQSEKELMEEAERKRQRLWCLDEDEIGLF |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length647
- Mass (Da)74,500
- Last updated2022-08-03 v1
- ChecksumF86DAE5DC943CCC7
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I |
Keywords
- Technical term