A0A8K0P7H3 · A0A8K0P7H3_LADFU
- ProteinNAD-dependent protein deacetylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids303 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- N6-acetyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]
- N6-hexadecanoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]This reaction proceeds in the forward direction.
- N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 56-60 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: AGLST | ||||||
Binding site | 66-68 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DFR | ||||||
Binding site | 139-142 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QNID | ||||||
Active site | 159 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 167 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 170 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 191 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 193 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 230-231 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TS | ||||||
Binding site | 254-256 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NRE |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Odonata > Epiprocta > Anisoptera > Libellulidae > Ladona
Accessions
- Primary accessionA0A8K0P7H3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MVLTALRLITGFIDA | ||||||
Chain | PRO_5035464678 | 16-303 | NAD-dependent protein deacetylase | |||
Sequence: CSVLKCRPPNIRNYSTSSETIKAVSSYIRDKCESIVVMAGAGLSTPSGIPDFRSPGTGLYHNLQKYNLPYPEAIFDIQYFVNNPMPFITLAQELYPGQKYRPNLAHYFVRLLHEKGKLLRMYTQNIDGLERLSGIPGDKLIEAHGTFHSASCIVCGDEHDPEIVKQTILSGKVHLCHCKGYVKPDIVFFGEQLPAKFWLHNLDTADTDLLIVLGTSLEVQPFASICDAVPRNTPRLLINRELVGSFGYRDFDNMLVGDIIESIRNLAKDIGWEEELSKLYETCEKRST |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-288 | Deacetylase sirtuin-type | ||||
Sequence: YSTSSETIKAVSSYIRDKCESIVVMAGAGLSTPSGIPDFRSPGTGLYHNLQKYNLPYPEAIFDIQYFVNNPMPFITLAQELYPGQKYRPNLAHYFVRLLHEKGKLLRMYTQNIDGLERLSGIPGDKLIEAHGTFHSASCIVCGDEHDPEIVKQTILSGKVHLCHCKGYVKPDIVFFGEQLPAKFWLHNLDTADTDLLIVLGTSLEVQPFASICDAVPRNTPRLLINRELVGSFGYRDFDNMLVGDIIESIRNLAKDIGWE |
Sequence similarities
Belongs to the sirtuin family. Class I subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length303
- Mass (Da)34,046
- Last updated2022-08-03 v1
- Checksum4F6467151A3D97D5
Keywords
- Technical term