A0A8K0K740 · A0A8K0K740_LADFU

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site129-136ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processcell division
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • ORF names
      J437_LFUL009530

Organism names

Accessions

  • Primary accession
    A0A8K0K740

Proteomes

Subcellular Location

Cytoplasm, cytoskeleton
Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-63Disordered
Domain121-261AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    40,817
  • Last updated
    2022-08-03 v1
  • Checksum
    95999456F318F12F
MAGSRKSRSVERLPKASLGGSKAQGKPILARGQVLTKKLTSSEVAGEEEKEERNAGPNGSTPMIPGFEGHMVEALEREILQKGPGVPWARVAGLKEAKSILQEAMVLPLLMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARSYSPSTIFIDEIDSLCSQRGSDSEHEASRRFKAELLIQMDGLNSETNEDGKTIMVLAATNHPWDIDEAFRRRFEKRIYIPLPDGEARVALLKLCLEGVATDKSLDMQAVADKLEGYTGSDISNVCRDAALMSMRRKVEGMTPEEIRNMRREEVELPVTSQDFDEAVQRCRCSVAKEDAARYEAWVQEFGSC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ308404
EMBL· GenBank· DDBJ
KAG8228972.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp