A0A8K0K4W1 · A0A8K0K4W1_LADFU

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Cellular Componentmitochondrial inner membrane
Cellular Componentneuromuscular junction
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentZ disc
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological Processamyloid precursor protein catabolic process
Biological Processamyloid-beta metabolic process
Biological Processcalcium ion transport
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of apoptotic process
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • ORF names
      J437_LFUL003906

Organism names

Accessions

  • Primary accession
    A0A8K0K4W1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane98-119Helical
Transmembrane145-167Helical
Transmembrane174-194Helical
Transmembrane206-225Helical
Transmembrane237-254Helical
Transmembrane260-276Helical
Transmembrane425-446Helical
Transmembrane452-471Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-76Disordered
Compositional bias46-60Polar residues
Region315-364Disordered
Compositional bias321-363Basic and acidic residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    54,555
  • Last updated
    2022-08-03 v1
  • Checksum
    31114C077A5FAA8A
MSDSETEEATEYTSLMDAHIGEVRPETVGDKTHRKRRPRPGRNSQSGAGEGANSVQENGMADPSVAAPGPPDPRNIVNELQNEEEEELKYGAKHVIKLFVPVSLCMLVVVATISSVTFYTTKDVYLVYTPFHEDSPDTSTKVWNAVANSLILMGVIVLMTVLLIVLYKNRCYKIIHGWLIVSSLMLLFIFSYLYLEEVLRAYNIPMDYITLAILMWNFGVVGMICIHWQGPLRLQQAYLIFVAALMALVFIKYLPEWTTWVVLGVISIWDLVAVLTPKGPLRILVETAQERNEQIFPALIYSSTLLYSYVNVVNGDEDEPTPPPRTSRSHPERTQVEGPPESRERVERRPAEPMPEIRSRQRQRDIMQATGSQIGNYGSTAQPQGQPEYRELEEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFQKALPALPISITFGLIFYFATREFVKPFTDSLASEQVFI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias46-60Polar residues
Compositional bias321-363Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ308371
EMBL· GenBank· DDBJ
KAG8228429.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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