A0A8K0JVS8 · A0A8K0JVS8_LADFU

Function

function

Purine nucleoside phosphorylase involved in purine salvage.

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; purine nucleoside salvage.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site9phosphate (UniProtKB | ChEBI)
Binding site51-52phosphate (UniProtKB | ChEBI)
Binding site84-85phosphate (UniProtKB | ChEBI)
Binding site156substrate
Binding site157phosphate (UniProtKB | ChEBI)
Site193Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Purine nucleoside phosphorylase
  • EC number
  • Short names
    PNP

Gene names

    • ORF names
      J437_LFUL006774

Organism names

Accessions

  • Primary accession
    A0A8K0JVS8

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain3-107Nucleoside phosphorylase
Domain122-215Nucleoside phosphorylase
Compositional bias471-492Polar residues
Region471-521Disordered
Compositional bias500-521Polar residues

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    521
  • Mass (Da)
    58,241
  • Last updated
    2022-08-03 v1
  • Checksum
    73E8F406EB80C76A
MNIGIIGGTGISHSRIFSTERYIELQTPFGDPSGKIAVGRLGNTRLFFIPRHGWKHTIPPSVINYRANIWALKALGCTHVIGTTASCSLNDNMKPGDLLMLSSFINRMNKLFYYSAQIDNYICHQNGLVVVVEGPRFPTVAESELYHSWGVDVISMTTVPEVCLAKELTLLYCCIASVSDYCSWNFQRKSLTVESVVKNFQENGIKVTNLIRRTLPWIETESWDEEIKLLEKTVQKSTYKKGIPIWAGLYFPPWIADKIALKQDNKVAAQKPLHTDVYGAFLNEPYLIKSFLPLSISKSNFSIPITSELSSNMGASISSPSTVTSKSTLMSIQPPRLHQNLQYTDSRSSNSSKCSQYPTKLHSKSSTFHNNLPTKSAFTDTLKSILASHFTPHKPFPEEIEIDILPVPYAIYPPGKLFPPPRYKLCDMLSFTVPEQIEPQEFPVVINIHPPPTVLNLPLCKLHQVQPFILPGNMNTGSSRSTLNSQIKGTPRKTKSSESKHSIQLSNLKSKTQTLPTVPDT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias471-492Polar residues
Compositional bias500-521Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ308144
EMBL· GenBank· DDBJ
KAG8222792.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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