A0A8K0IP53 · A0A8K0IP53_COCNU

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site122ATP (UniProtKB | ChEBI)
Binding site185-186ATP (UniProtKB | ChEBI)
Binding site210-213ATP (UniProtKB | ChEBI)
Binding site211Mg2+ (UniProtKB | ChEBI); catalytic
Site212Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site239-241substrate
Active site241Proton acceptor
Binding site284-286substrate
Binding site340substrate
Binding site398-401substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      COCNU_11G006160

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Arecaceae > Arecoideae > Cocoseae > Attaleinae > Cocos

Accessions

  • Primary accession
    A0A8K0IP53

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain114-422Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,578
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    35CD9E381FAE7B74AFD6E9A612BAE0D4
MDFAVPPNSNTGPVTTTGDDNLTFTTDFSLPPITLQKLPHLSDYVPNLTTLTSPIDRSPFYHPFPGFYLSSSDLILRHILFDLSSSATDGGGHLLAYHRAGPRRTIHFDPDAVRAAIVTCGGLCPGLNTVIRELVVGLWDLYGVRQIFGVPSGYRGFYSMEPMKLDPKMVHNWHKRGGTVLATSRGGFDLEKIVDAIEQRGFNQLYVIGGDGTMRGAVKIFREIQRRELNISITGIPKTVDNDIGIIDRSFGFQTAVEMAQEAIDAAHVESESAVNGIGLVKLMGRSTGHIALHATLSSRVVDCCLIPENDFYLEGKGGLFEFLDQRLKQNGHAVIVVAEGAGQDMIPRTGKQKEEKDESGNPVFLDVGPWLKSELKKWWEQDHPGELFTVKYIDPTYMIRAVPANATDNLYCTLLAHSAIHGVMAGYTGFVPGPINGNYAYIPMEEVAVARNVVDTKDHKWAWVRSVTSQPDFQKC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM017882
EMBL· GenBank· DDBJ
KAG1363789.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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