A0A8K0A675 · A0A8K0A675_BRALA

Function

function

Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.

Catalytic activity

  • (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.232 (UniProtKB | ENZYME | Rhea)
  • 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H+ = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+
    This reaction proceeds in the forward direction.
  • lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin A1 + NAD+ = 15-oxo-prostaglandin A1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E1 + NAD+ = 15-oxoprostaglandin E1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E2 + NAD+ = 15-oxoprostaglandin E2 + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.141 (UniProtKB | ENZYME | Rhea)
  • resolvin D1 + NAD+ = 17-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D1 + NAD+ = 8-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 16-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 7-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin E1 + NAD+ = 18-oxo-resolvin E1 + NADH + H+
    This reaction proceeds in the forward direction.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • EC number
  • Alternative names
    • Eicosanoid/docosanoid dehydrogenase [NAD(+)]
    • Prostaglandin dehydrogenase 1

Gene names

    • Name
      HPGD
    • ORF names
      BLAG_LOCUS22191

Organism names

Accessions

  • Primary accession
    A0A8K0A675

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    28,485
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    F8D95D51A0FE47C5118C15838555A7F2
MQLRGKVALVTGAAQGLGKGFSEAMLNRGAKVALVDMNESMGRETEKELSVKYGYDNVVFLRCDVTNKDQLESVFRRTVEEFGTLDIVVNNAGVSKRSHWELILEVNLMETGPVYSAAKHGVVGLSRSLGLGPHLLQRGVRVCALCPTQTDTDIHPARLQRDPEMQKMADEHWRLVDSEGGLIKISQVVDGFLQLVEDDSKNGAVMRVTLQRGVDYQPYGRGGEGVPYTRRAARSKLRNTEQVSDFFIPAWKMFRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OV696692
EMBL· GenBank· DDBJ
CAH1269591.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help