A0A8J8YT76 · A0A8J8YT76_MACMU
- ProteinKelch-like ECH-associated protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids624 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Pathway
Protein modification; protein ubiquitination.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | protein ubiquitination |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKelch-like ECH-associated protein 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A8J8YT76
Proteomes
Interaction
Subunit
Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1. Interacts with NFE2L2/NRF2; the interaction is direct. Forms a ternary complex with NFE2L2/NRF2 and PGAM5. Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation. Interacts with NFE2L1. Interacts with BPTF and PTMA. Interacts with MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2. Interacts with HSP90AA1 and HSP90AB1.
Sequence
- Sequence statusComplete
- Length624
- Mass (Da)69,818
- Last updated2022-05-25 v1
- MD5 Checksum6AAB9D2D07382C2E933402132C898854
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM001271 EMBL· GenBank· DDBJ | EHH29625.1 EMBL· GenBank· DDBJ | Genomic DNA |