A0A8J7ZB58 · A0A8J7ZB58_9ARCH
- ProteinK(+)-insensitive pyrophosphate-energized proton pump
- GenehppA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids719 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Catalytic activity
- diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate
Cofactor
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 486 | Determinant of potassium independence | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameK(+)-insensitive pyrophosphate-energized proton pump
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Asgard group
Accessions
- Primary accessionA0A8J7ZB58
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-34 | Helical | ||||
Sequence: IIIALIAGVISIIVAIIFSIIVL | ||||||
Transmembrane | 62-80 | Helical | ||||
Sequence: YRILTIFVLILFLVILFFL | ||||||
Transmembrane | 106-128 | Helical | ||||
Sequence: ALAYLVGSAASMFAGYLGMIIGV | ||||||
Transmembrane | 148-175 | Helical | ||||
Sequence: VAFFGGSVMGLAVVGSALIGVSVIFWIF | ||||||
Transmembrane | 181-202 | Helical | ||||
Sequence: ILGFSFGASTIALFMKCGGGIY | ||||||
Transmembrane | 249-268 | Helical | ||||
Sequence: LFDSFVASILAAMLLAYTLF | ||||||
Transmembrane | 280-301 | Helical | ||||
Sequence: VIYPIVISSVGLAASLFGILLI | ||||||
Transmembrane | 313-336 | Helical | ||||
Sequence: LNLGTYIATAAFAALGALFVFILI | ||||||
Transmembrane | 356-374 | Helical | ||||
Sequence: CVVIGLLAGVLIGWISDIF | ||||||
Transmembrane | 395-421 | Helical | ||||
Sequence: VVILSGFAYGMLSVVPPALGIAAAMIL | ||||||
Transmembrane | 427-446 | Helical | ||||
Sequence: GVFGVAMAAVGMLAIVGTVV | ||||||
Transmembrane | 487-509 | Helical | ||||
Sequence: AITKGFAIGAANLAVFALLFSFV | ||||||
Transmembrane | 521-546 | Helical | ||||
Sequence: LLNINVLTGAFIGVVAPVLFSALLVL | ||||||
Transmembrane | 605-633 | Helical | ||||
Sequence: LLVGVLFGIAALGAFLVGAILSGFVFAIF | ||||||
Transmembrane | 682-703 | Helical | ||||
Sequence: INTLLVVMVLTATIFLGLLLLI |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length719
- Mass (Da)75,602
- Last updated2022-05-25 v1
- ChecksumBC73772BFE892178