A0A8J7F8F8 · A0A8J7F8F8_9GAMM
- ProteinCytochrome c oxidase subunit 2
- GenecoxB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Pontibacterium
Accessions
- Primary accessionA0A8J7F8F8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 48-69 | Helical | ||||
Sequence: TIFWVCVAIGAVVFGVMLYSIV | ||||||
Transmembrane | 90-112 | Helical | ||||
Sequence: IIWTVVPFVILVGMAVPATATLI |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-118 | Cytochrome oxidase subunit II transmembrane region profile | ||||
Sequence: AAAEWQVNLGPGVTEISRAVYDLHMTIFWVCVAIGAVVFGVMLYSIVHHRKSRGAKAHNFHENTLVEIIWTVVPFVILVGMAVPATATLIKMYDQS | ||||||
Domain | 119-256 | Cytochrome oxidase subunit II copper A binding | ||||
Sequence: EAELDIQVTGYQWKWRYQYLGEDIDFFSSLSTPREQISNDETKGEHYLLEVDNAMVIPAGKKVRLLLTANDVIHSWWVPDLAVKKDAIPGFINEAWTIAPEPGIYRGQCAELCGKDHGFMPIVVDVRSEEDFNQWLVE | ||||||
Domain | 276-356 | Cytochrome c | ||||
Sequence: ELMAKGEEVYNRACAACHQPNGEGIPGAFPALKGSPMMVGDPAAHIDVVLNGKSGTAMQAFRDQLSAVELAAVITYERNAW |
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)41,126
- Last updated2022-05-25 v1
- ChecksumBD2690F5973399AA
Keywords
- Technical term