A0A8J7F7T1 · A0A8J7F7T1_9GAMM

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13Zn2+ 1 (UniProtKB | ChEBI)
Binding site15Zn2+ 1 (UniProtKB | ChEBI)
Binding site15-17substrate
Binding site41substrate
Binding site98Zn2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site98Zn2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site135Zn2+ 2 (UniProtKB | ChEBI)
Binding site135substrate
Binding site173Zn2+ 2 (UniProtKB | ChEBI)
Binding site218substrate
Active site246
Binding site246Zn2+ 1 (UniProtKB | ChEBI)
Binding site250substrate
Binding site262substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • ORF names
      IOQ59_05350

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • N1Y112
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Oceanospirillaceae > Pontibacterium

Accessions

  • Primary accession
    A0A8J7F7T1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue98N6-carboxylysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-309Amidohydrolase-related

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    345
  • Mass (Da)
    37,818
  • Last updated
    2022-05-25 v1
  • Checksum
    C75009A819BB56D5
MNTLTIQTPDDWHLHLRDGDMLPETVAATARCFQRAIIMPNLVPPVTNAEMAMAYRQRILDARPEGSDFNPLVTLYLTNDTTAQDIIDAKAAGVVASKLYPAGATTNSAAAVSQLEAMYPVFEVMAEQGMLLLVHGEVTDSHVDIFDREKEFIDQKLAKIVESFPTLKVVFEHITTGDAAQFVQGSSDNVAATITPQHLLLNRNDLLVGGVRPHNYCLPVLKRSTHQEALRAVVQSGSPKFFLGTDSAPHAKEAKENACGCAGCYSAWSAIELYAHVFEELDALDKLEGFASHYGPDFYGLPRNEGSITLIREDWTIPGEIALPSGKPIVPFFANQTVHWKVQQG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADEYS010000004
EMBL· GenBank· DDBJ
MBE9396685.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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