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A0A8J7EKS1 · A0A8J7EKS1_9CYAN

  • Protein
    4-hydroxy-tetrahydrodipicolinate reductase
  • Gene
    dapB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-18NAD+ (UniProtKB | ChEBI)
Binding site108-110NAD+ (UniProtKB | ChEBI)
Active site164Proton donor/acceptor
Binding site165(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site168Proton donor
Binding site174-175(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      IQ268_02835

Organism names

  • Taxonomic identifier
  • Strain
    • LEGE 06141
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Oculatellales > Oculatellaceae > Oculatella

Accessions

  • Primary accession
    A0A8J7EKS1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-137Dihydrodipicolinate reductase N-terminal
Domain140-275Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    29,593
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    8BC40ADFEA8D8DB1E88282C5717EFFE5
MVSQASIPVVINGAAGKMGREVVKAVAQAEDMNLIGAIDRNPALVGKDIGEVAGCGELEIPVLPDLEATLAMAAQEKQLPVMVDFTHPDSVYENVRSAIAYGVRPVIGTTGLSPEQIQELADFADKASTGCLIIPNFSIGMVLLQQAAARASQYFDHVEIIELHHNQKADAPSGTAIQTAQLLEEFGKPYNPPRVNETEKMSGARGTCTENGIRIHSIRLPGLIAHQEVIFGAPGEIYTLRHDTSDRACYMPGVLLAIRKVLQLKTLMYGLDKIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADEWO010000002
EMBL· GenBank· DDBJ
MBE9177512.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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