A0A8J7BJG2 · A0A8J7BJG2_9CYAN

  • Protein
    Bifunctional pantoate ligase/cytidylate kinase
  • Gene
    panC/cmk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site35-42ATP (UniProtKB | ChEBI)
Active site42Proton donor
Binding site66(R)-pantoate (UniProtKB | ChEBI)
Binding site66beta-alanine (UniProtKB | ChEBI)
Binding site158-161ATP (UniProtKB | ChEBI)
Binding site164(R)-pantoate (UniProtKB | ChEBI)
Binding site187ATP (UniProtKB | ChEBI)
Binding site195-198ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional pantoate ligase/cytidylate kinase

Including 2 domains:

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      panC/cmk
    • ORF names
      H6F59_06195

Organism names

  • Taxonomic identifier
  • Strain
    • FACHB-141
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nodosilineales > Nodosilineaceae > Nodosilinea

Accessions

  • Primary accession
    A0A8J7BJG2

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-288Pantoate--beta-alanine ligase
Region289-523Cytidylate kinase
Domain297-518Cytidylate kinase
Region454-489Disordered
Compositional bias472-489Basic and acidic residues

Sequence similarities

Belongs to the cytidylate kinase family. Type 1 subfamily.
Belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
In the N-terminal section; belongs to the pantothenate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    523
  • Mass (Da)
    57,035
  • Last updated
    2022-05-25 v1
  • Checksum
    CD6C4134423E4775
MRVLKTVEGVKRYLGQARRQQNAEDGVAVGLVPTMGNLHRGHLSLIERARLENSVVVVSIFVNPLQFGPQEDLARYPHTPEQDLRLCEQAGVDAVFMPTVTAFYGAAQPHSDAMTRVMPSKAMVAVLCGSHRPGHFEGVATVVTKLLSLVAPDRAYFGYKDAQQLAILKRLAHDLNLPSQLVGCPTVREASGLALSSRNSYLSEVERQQAAVIYRGLLAAQQCFQAGERLSSALTAAVAAELAQEPSLHPQYVELVHPETLQPLERVETLGMLAVAAHLGATRLIDNILLRDRQPIVAIDGPAGAGKSTVARQVAQRLNLLYLDSGAMYRAVTWLVLERGIDVQDEVAIAELVQDCEIRLEASGNDSAFAAYPSRIWLNGQEVTQAIRSTAVTAAVSAVSAQPTVREVLLRQQQQYGITGGVVMEGRDIGTQVFPQAELKVFLTASVGERARRRQRDLAAQEQPAVSLSDLEQAIDDRDRKDSSRRVSPLRQADDAIALNTDGLAIEDVVNKIVQLFESRVER

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias472-489Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACJPP010000007
EMBL· GenBank· DDBJ
MBD2111416.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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