A0A8J6Q0Y9 · A0A8J6Q0Y9_9FLAO

  • Protein
    Imidazole glycerol phosphate synthase subunit HisH
  • Gene
    hisH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site77Nucleophile
Active site175
Active site177

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydrolase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH
      (IGPS subunit HisH
      )

Gene names

    • Name
      hisH
    • ORF names
      ICJ85_01850

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IP7
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A8J6Q0Y9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-191Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    21,563
  • Last updated
    2022-05-25 v1
  • Checksum
    2BB3763B9B93D988
MKLVIINYGAGNIKSIQFAFKRLGVDAILSNNPEEILAADKIIFPGVGEASSAMAMLKETGLDQLIPKLKQPVLGICLGMQLLCEFTEEGNTKGLGVFKTVVKRFDNPVKVPQMGWNIIKELKSKLFKGIKEKEYMYLVHSYYAEHCPETIATTDYGLNYASALQHKNFYGVQFHPEKSSLAGEQILKNFLEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACVXD010000001
EMBL· GenBank· DDBJ
MBD0822753.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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