A0A8J6L4L8 · A0A8J6L4L8_TENMO
- ProteinMultifunctional fusion protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids3456 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Activated by threonine and tyrosine phosphorylation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 139 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2944-2950 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: CAAPGSK | ||||||
Binding site | 2974 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 3001 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 3028 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 3081 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | DNA-directed RNA polymerase complex | |
Cellular Component | nuclear lumen | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed 5'-3' RNA polymerase activity | |
Molecular Function | MAP kinase activity | |
Molecular Function | tRNA (cytidine-5-)-methyltransferase activity | |
Molecular Function | tRNA binding | |
Biological Process | DNA-templated transcription | |
Biological Process | tRNA methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameDNA-directed RNA polymerase subunit
- EC number
- Recommended nameMitogen-activated protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrio
Accessions
- Primary accessionA0A8J6L4L8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 109-403 | Protein kinase | ||||
Sequence: FDIQKRLGKGAYGIVWKAIDRKTKDVVAVKKIFDAFRNQTDAQRTFREIMFLQSLKNHPNIVKLHSIHRAANNSDIYLGFEYMETDLHNVIKKGILKDIHKKYIMYQLFKAVKYIHSGNVIHRDLKPSNILLDIMCRCKIADFGLARSLSQGSEGNLSETDPTLTDYVATRWYRAPEILIANRRYTKGIDMWSLGCILAEITAGKPIFPGSSTVNQVEKIMATIPTPSQEDINLVCVSGVGTSMIKNASSVEKVPLHAVLGKNGCKSAISLINKLLVFNPNKRLTAEEALEHEYV | ||||||
Region | 464-483 | Disordered | ||||
Sequence: SRISKHYGKPPPSMKEPKSC | ||||||
Region | 713-734 | Disordered | ||||
Sequence: MDVGKEGEDPNQAKKQGHGGCG | ||||||
Region | 2513-2536 | Disordered | ||||
Sequence: SPTSLSPLKDATPTPKYRSPSYYS | ||||||
Domain | 2826-3189 | SAM-dependent MTase RsmB/NOP-type | ||||
Sequence: FITSLKTDLPATFRITGSKGEACKMLETVQGQFIKDCLNQEGVDGKPPNIFPLPWYPNKLAWQLELTRKDIRRCEAYYKLHNFLISETEHGTISRQETVSMIPPLLLDVQPHHKVLDMCAAPGSKTAQLLEILHANDDPIPSGYVIANDVDNKRCYMLVHQAKRLNSPCVAVINHDSAILPNLSASLPDGSVEQVQFDRVLCDVPCSGDGTLRKNPDIWMKWTPANGLNLHGIQSRIVRRGAELLTVGGRLVYSTCSINPVENEAVIHRLLAETDGALQLVDVSSSLPGLKYVPGMESWLVSSRNLEFYTSYEEVDEKWRTTIRPQMFPPKPEDKASYNLHRCMRILPHHQNTGAFFVAVLEKL | ||||||
Region | 3205-3227 | Disordered | ||||
Sequence: GEQIANKKRENEDDLPQNQRKKR | ||||||
Region | 3437-3456 | Disordered | ||||
Sequence: LEEDEEEASKEEDKPSGDSQ |
Sequence similarities
Belongs to the RNA polymerase beta' chain family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,456
- Mass (Da)387,770
- Last updated2022-05-25 v1
- Checksum86A868F548A5A714
Keywords
- Technical term