A0A8J6L4L8 · A0A8J6L4L8_TENMO

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by threonine and tyrosine phosphorylation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site139ATP (UniProtKB | ChEBI)
Binding site2944-2950S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2974S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3001S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3028S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site3081Nucleophile

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Cellular Componentnuclear lumen
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular FunctionMAP kinase activity
Molecular FunctiontRNA (cytidine-5-)-methyltransferase activity
Molecular FunctiontRNA binding
Biological ProcessDNA-templated transcription
Biological ProcesstRNA methylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    DNA-directed RNA polymerase subunit
  • EC number
  • Recommended name
    Mitogen-activated protein kinase
  • EC number

Gene names

    • ORF names
      GEV33_011658

Organism names

  • Taxonomic identifier
  • Strain
    • Stoneville
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrio

Accessions

  • Primary accession
    A0A8J6L4L8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain109-403Protein kinase
Region464-483Disordered
Region713-734Disordered
Region2513-2536Disordered
Domain2826-3189SAM-dependent MTase RsmB/NOP-type
Region3205-3227Disordered
Region3437-3456Disordered

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,456
  • Mass (Da)
    387,770
  • Last updated
    2022-05-25 v1
  • Checksum
    86A868F548A5A714
MVREKMKQSKSRALIFIYSPSGGARSEGAPWRAVAGARGGQRGGAARFKFENDRVMSPDVTVTLLTSIWKNVSLDSFSTVTGEFSWTERKMPHPKEKIFEIDEHISKRFDIQKRLGKGAYGIVWKAIDRKTKDVVAVKKIFDAFRNQTDAQRTFREIMFLQSLKNHPNIVKLHSIHRAANNSDIYLGFEYMETDLHNVIKKGILKDIHKKYIMYQLFKAVKYIHSGNVIHRDLKPSNILLDIMCRCKIADFGLARSLSQGSEGNLSETDPTLTDYVATRWYRAPEILIANRRYTKGIDMWSLGCILAEITAGKPIFPGSSTVNQVEKIMATIPTPSQEDINLVCVSGVGTSMIKNASSVEKVPLHAVLGKNGCKSAISLINKLLVFNPNKRLTAEEALEHEYVSAFHDPDQEIELSHDIVIPFKDDVRLSVEDYRNKLYEIMSTHHNRHKSSCKTKAFTPELPSRISKHYGKPPPSMKEPKSCATRSEPRINYNARANDHVVTVIKSDSKVITKQNLHFPKNLNKTQVNDRQHVRENGMKKRFANVKNGYPAYNNYHQSHGIISQSTLMGLKTSGLRNRFLSDQRRMSVTEGGIRFPETMEAGRPKMGGLMDPRQGVIDRHSRCQTCAGNMTECPGHFGHIDLAKPVFHVGFVTKTIKILRCVCFYCSKLLVSPNNPKIKEVVMKSKGQPRKRLAFVYDLCKGKNICEGGDEMDVGKEGEDPNQAKKQGHGGCGRYQPNIRRIGLDLTAEWKHLNEDSQEKKIALSAERVWEILKHITDEECFILGMDPKFARPDWMIVTVLPVPPLPVRPAVVMYGSARNQDDLTHKLADIIKANNELQKNEAAGAAAHVIGENIKMLQFHVATLVDNDMPGMPRAMQKSGKPLKALKSRLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRIDQVGVPRSIAQNLTFPEIVTPFNFDKMLELVQRGNSQYPGAKYIIRDNGERIDLRFHPKSSDLHLQCGYKVERHIRDGDLVIFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSCTSPYNADFDGDEMNLHVPQSMETRAEVENLHITPRQIITPQANKPVMGIVQDTLTAIRKMTKRDVFIEKEQMMNLLMFLPIWDGKMPRPAILKPKPLWTGKQIFSLIIPGNVNMIRTHSTHPDDEDDGPYKWISPGDTKVMVEHGELIMGILCKRTLGTSAGSLLHICMLELGHEVCGRFYGNIQTVVNNWLLLEGHSIGIGDTIADPQTYLEIQKAIKKAKEDVIEVIQKAHNMELEPTPGNTLRQTFENQVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIPFGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVHYDGTVRNSVGQLIQLRYGEDGLCGEMVEFQTLPTVKLSNKAFERKFRFDPSNERYLRRVFNEEVIKDLMGSGEVISELETEWEQLQKDREALRQIFPSGESKVVLPCNLQRMIWNVQKIFHINKRAPTDLSPLRVIQGVRELLNKCVIVAGEDRLSKQANENATLLFQCLVRSTLCTKCVSEEFRLSTEAFEWLIGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEIINISKKPKAPSLTVFLTGAAARDAEKAKNVLCRLEHTTLRKVTANTAIYYDPDPQNTVIPEDQEFVNVYYEMPDFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDDGKFGDGADEDVDKMDDDMFLRCIEANMLSDMTLQGIEAISKVYMHLPQNDSKKRIVITETGEFKAIAEWLLETDGTSMMKVLSERDVDPVRTFSNDICEIFSVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEETVDVLMDAASHAEVDPMRGVSENIIMGQLPRMGTGCFDLLLDAEKCKMGIPIPQAHGADIMSSGMFFGSAATPSMSPGGAMTPWNQGTTPYVGSAWSPHSTFDGKRYDSWRTGVLAVGGVRRVRNVSGLRCLVADSTVSGDVAVHGLASRSVAVVQSLEPILPAHFSIYDAGFARVLSKLSGIFSNESQLQSHISKLLAHEPELQSXXXXSHISKLLAHEPELQSDVSFVLAHIAELFAHESQLQSHITELFPNQSELQSHLAELLSDESELQPHLAELLSDESQLQSHVAELLSDESQLQSHLAELLSDESQLQSFVAEVHTGVAKLLAHEPELQSVVATVFSGVAELFAFFTQILSDFSKLLAHFAVVRRRKSTVLTDFPELFTDVAELLAVESTAHSGCEFAVLTVVSELLAEFAELFTDESSIFTAQYKVFADVTHLHADVPELLAGVTSVLASTTEVLAHPVLRLNHQLSSWTSKRTGYIIEENHNSKNPTYYSTPPNYATSLPTNAGASVVCNAPSPYYSPESPTSLSPLKDATPTPKYRSPSYYSPLSPTSPDSYRSPYYLASSPSQYYFTSPQRDWSPTYYPFSPKQYSSSTCSPLSSTYCSAASNYSSFSSTSCPTSPSHSVRSSTLSSPISCPPSPYYSRSSSTYTFSSPTPYATPPHSPAPPNYLPLSPIYSPALPDNSSRPKFRFSYSNNDERTASSKYCPSSVYCFSSPPESPDYSSFSPEYYSPVFSPTYKYPDISMTNRRPRARYNGTSSPIYCPLSPQLTPSPSSCPSSSIIESLELRDTDVALNPPVASKSDTRKPYMDIVKENEKFVKYYETQNVCKSEEFDEFITSLKTDLPATFRITGSKGEACKMLETVQGQFIKDCLNQEGVDGKPPNIFPLPWYPNKLAWQLELTRKDIRRCEAYYKLHNFLISETEHGTISRQETVSMIPPLLLDVQPHHKVLDMCAAPGSKTAQLLEILHANDDPIPSGYVIANDVDNKRCYMLVHQAKRLNSPCVAVINHDSAILPNLSASLPDGSVEQVQFDRVLCDVPCSGDGTLRKNPDIWMKWTPANGLNLHGIQSRIVRRGAELLTVGGRLVYSTCSINPVENEAVIHRLLAETDGALQLVDVSSSLPGLKYVPGMESWLVSSRNLEFYTSYEEVDEKWRTTIRPQMFPPKPEDKASYNLHRCMRILPHHQNTGAFFVAVLEKLKPLSAKEKSFKANEVGEQIANKKRENEDDLPQNQRKKRRNEGYREDPFVFFKEEEPVWDEIKSFYEISDTFDSKCLLTRCHIGKKKNIYLTSNAVRDLVVQNQNVIKFINTGVKAFVRCDNKNMKCAFRIANDGLESIYPYIGDSRKIDIPREDLITLLMNDNPEKSPPITSLSEVIQKQVENLSPGSCVLIYKEDIEGNDEPLVIHISGWRGTTSLRCYMSQHSTVHLLRLLGGDISKYDVNKFKKLEEDEEEASKEEDKPSGDSQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABDTM020027017
EMBL· GenBank· DDBJ
KAH0811134.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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