A0A8J6G844 · A0A8J6G844_MICOH
- ProteinPhosphatidylinositol-4,5-bisphosphate 4-phosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids433 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | EKC/KEOPS complex | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | phagocytic vesicle membrane | |
Molecular Function | acyltransferase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | tRNA modification | |
Biological Process | tRNA threonylcarbamoyladenosine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-4,5-bisphosphate 4-phosphatase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Arvicolinae > Microtus
Accessions
- Primary accessionA0A8J6G844
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 166-187 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length433
- Mass (Da)46,177
- Last updated2022-05-25 v1
- MD5 Checksum343EFE0ED93D6C96CDBD9830380A1571
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 46-80 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAATJU010024361 EMBL· GenBank· DDBJ | KAH0505879.1 EMBL· GenBank· DDBJ | Genomic DNA |