A0A8J6BQ15 · A0A8J6BQ15_ZIZPA

Function

function

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site1467

GO annotations

AspectTerm
Cellular ComponentMCM complex
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functiondihydrofolate reductase activity
Molecular FunctionDNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Molecular Functionmetal ion binding
Molecular Functionthymidylate synthase activity
Biological ProcessDNA replication initiation
Biological ProcessDNA unwinding involved in DNA replication
Biological ProcessdTMP biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA helicase
  • EC number

Gene names

    • ORF names
      GUJ93_ZPchr0011g27389

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Zizaniinae > Zizania

Accessions

  • Primary accession
    A0A8J6BQ15

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-40Polar residues
Region1-61Disordered
Compositional bias41-61Acidic residues
Region153-220Disordered
Compositional bias205-220Acidic residues
Domain524-730MCM
Domain1081-1258DHFR

Sequence similarities

In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,550
  • Mass (Da)
    174,157
  • Last updated
    2022-05-25 v1
  • Checksum
    78813C325E97DE59
MDDSENNAPSTPGSPGFSTDRLPPNTTTSRGATDPSSYSDDDNNSAEEAEVDPNVLPEDDGAAEIVADEEDEDGEDLFNDNYLDDYRRMDGQDQYESVGLDDSIEDERNLDEIIADRRAAEAVLDARDVMTGATAERKLPRMLDDLDMDEDMNFRRPKRHRANFRPPREPRTPRSDDDGDGATPSSPGRSQRGMYSGGDVPMTDQTDDDPYEDEFDEEDEMNMYRVQGTLREWVTRDEVRRFIAKKFKEFLLTYVNPKNEQGEFEYVRIINEMVLANKCSLEIDYKQFIYIHPNIAIWLADAPQSVLEVMEEVAKNVVFDLHKNYRNIHQKIYVRITNLPVYDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCSKCGTVLGPFFQNSYTEVKVGSCPECQSKGPFTINVEQTIYRNYQKLTLQESPGIVPAGRLPRYKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVVEANYVAKKQDLFSAYKLTDEDKAEIEKLSKDPRISERIVKSIAPSIYGHEDIKTAIALAMFGGQEKNVRGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGHRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPLGGRYDSSKTFTQNVELTDPIISRFDVLCVVKDIVDPFTDEMLARFVVDSHARSQPKGANLEDRVATDVEDDPLTAARQADPDILSQDMLKKYITYSKLNVFPKIHDADLDKISHVYAELRRESSHGQGVPIAVRHIESIIRMSEAHARMHLRNYVSQEDVDMAIRVLLDSFISTQKFGVQKALQKNFRKYMTYKKDYNELLLLLLRTLVKDVLHFEEIVSGSTTRLTHIDVKVDDLKNKAQEYEIYDLRPFFSSKHFKDNNFVLDEGRGIITRCPLGLIPNPSSSTLSPPSRHLLLLLLLLLPPLQRAARWLGLGAPSQRRCIAAQGKGGAVGVALSSAPPIARFFSISRGPISQFKKPQSLDASSKLSSCCFVQTQPIAMSTTLSNGVSQNGPQRNYQVVVAATCDGGIGKDGDLPWKLPGDLKFFKDITRTTVDPTKKNAVIMGRKSWESLPLQARPLSGRLNIILTRSGSFDFATVENVVICGSMNSALELLASTPYCLSIEKVFVIGGGQILREYLNGPSCEAIHITDIQSSMECDTFIPPIDLSVFQPWYSSLPVVENNIRHSFVTFVRVRKTMAEAHDSNGKESTNDGTKSDKFEIENFSFLPKLIFGRHEEYHYLNLVEDIIRSGAQKNDRTGTGTISKFGCQMRFNLRNSFPLLTTKKVFWRGVVEELLWFISGSTSAKVLQEKGIHIWDGNASREYLDSVGLAHREEGDLGPVYGFQWRHFGADYTDMHADYTGKGFDQLMDVIDKIKNNPDDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTYMIAQVCGLSPGDFVHVIGDAHVYRTHVRALEEQIQKLPKPFPI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J6BKL4A0A8J6BKL4_ZIZPAGUJ93_ZPchr0011g273891396

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-40Polar residues
Compositional bias41-61Acidic residues
Compositional bias205-220Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAALK010000081
EMBL· GenBank· DDBJ
KAG8089831.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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