A0A8J5XBA1 · A0A8J5XBA1_DIALT

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      KFE25_004894

Organism names

Accessions

  • Primary accession
    A0A8J5XBA1

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-27
ChainPRO_503528885228-863DNA topoisomerase 2

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region314-365Disordered
Domain660-762Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    863
  • Mass (Da)
    88,339
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    28F2FBF4289AFA781BC175FF66248E42
MATRSGRWCTALLVLAVLAALAQRAGGAAMAGARRPGGVLASRGSRVGATATAPGGATAAAAAGAAAASRGYSADDITVLEGLEPVRKRPGMYIGSTGPAGLHHLVYEVVDNSVDEALAGHCTRIRVLLETDGSVVVEDDGRGIPCGTHAKTGRSALETVMTVLHAGGKFGDNGYSVSGGLHGVGVSVVNALSERCVVEVRREGHEHRMGFARGVPTGSLERTPLVLAEPPPPPPKVIAAAAAAGAPRRLGRWRERATGTRVRFLADGTIFKHGVSYDAETLARRFDQLAYLNAGLVIELVDLRPPAARARASARARADADVGDGGADDGDGGGGGGDGGADAAAETGAGAEAGAEAEAEAAGAPAAGADDGMAAAFAETGFLPAGARAWSFEHAGGIEEMVADLCGGKTLAATLEGGGLDGGGAQGAATTAAAKPRRAGANGAGAGAPAALLCATPIVISGERRGVGIEIALQWAATSYSERLLGFANGIHTPAGGSHVDGLKVALTRVVNAALKRAAAGGGPAAAATGAGAGSGSAAPKIKGAKDVGGSLSGEFIREGLTAVISVKLTNPEFEGQTKSKLGSSEVRSAVDSLVCEQLATYFDFNPKVLSAVAAKAIAAARAAEAAKAARDLLRSKSVMHRTVLPGKLSDCQSDDPRVSEIFLVEGDSAGGSAKQGRDRRTQAVDEKRMYKNTEVQALVTSLGLGVRGEGIADGTLRYHRVIVMTDADVDGAHIRTLLLTFFYRYAPELIHGGYVYVACPPLFKVAVGQRTVYATSDEEASVLLRQSPKATIQRFKGLGEMMPEELWRTTMDPKRRMLKQISVLDAARADTVFTTLMGENVAPRKAFIENRAQHLEPDEIDI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGTXO010000016
EMBL· GenBank· DDBJ
KAG8463383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help