A0A8J5IPT9 · A0A8J5IPT9_9STRA

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site134-140GTP (UniProtKB | ChEBI)
Active site135Proton acceptor
Binding site135Mg2+ (UniProtKB | ChEBI)
Binding site135-138IMP (UniProtKB | ChEBI)
Binding site160-163IMP (UniProtKB | ChEBI)
Binding site162Mg2+ (UniProtKB | ChEBI)
Binding site162-164GTP (UniProtKB | ChEBI)
Active site163Proton donor
Binding site251IMP (UniProtKB | ChEBI)
Active site262
Binding site265IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site342IMP (UniProtKB | ChEBI)
Binding site357IMP (UniProtKB | ChEBI)
Binding site417-423substrate
Binding site421IMP (UniProtKB | ChEBI)
Binding site423GTP (UniProtKB | ChEBI)
Binding site449-451GTP (UniProtKB | ChEBI)
Binding site531-533GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      JG688_00010600

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NZFS 4037
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora

Accessions

  • Primary accession
    A0A8J5IPT9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    554
  • Mass (Da)
    60,377
  • Last updated
    2022-05-25 v1
  • Checksum
    B148FC41EF9F08E4
MRLDVVSKAARAAQRFSAQCQGQQFRTAHASATLRAALAVEASQANQKGRSAGLLPVAAAVALMGAAGVASMDDNSAAKCEGAAKPVSREAVTQAMLKEVVTKLNRIESAVANPHRHTDGLNVGVDVVLGAQWGDEGKGKLVDSLSQSYDVIVRVAGGSNAGHTIVHEGKKYKFHLVPSGILNPNAICIIGNGVVVHLPSFLEELEELKRMGIDYEGRILISDRAHMVLDLHQEVDGINELRRGRNKIGTTKKGIGPAYSSKMLRNGVRVGDLRYFDDFTEKMRDLVKFYKDNYPELEADVEAEIKVYNDMKDKILDMTVDSVSYLNNAYVAGKKILVEGANATMLDIDFGTYPYVTSSNPSIGSVCTGGGISPNRLNGIIGIVKAYCTRVGEGPFPTELHDEVGEHLGTVGAEFGTTTGRARRCGWLDIPQMRYSNMVNGFTELNLTKLDVLTGLDKVKIGVAYWHKGKKLDGMPSNLQLLQDSVVEYEELEGWSEDISKCKTFEELPVAAQKYVLRVEELLGTHIKWIGVGPDRFDVITRPHPLEKAYISSN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAENGY010000681
EMBL· GenBank· DDBJ
KAG6958213.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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