A0A8J5IKC9 · A0A8J5IKC9_9STRA

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-22ATP (UniProtKB | ChEBI)
Binding site43a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site64-66a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site91-94a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site98CMP (UniProtKB | ChEBI)
Binding site133ATP (UniProtKB | ChEBI)
Binding site139a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site150a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site178ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      JG688_00009864

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NZFS 4037
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora

Accessions

  • Primary accession
    A0A8J5IKC9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region132-142LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    22,071
  • Last updated
    2022-05-25 v1
  • Checksum
    20453A06F157C290
MSATLAKKILFVLGGPGAGKGTQCAKLVEKYGFVHLSAGDLLREERQSGSENGELIDRMIKEGQIVPVKITLNLLQQAMVKSGRDLFLIDGFPRNFDNLQGWQEEMAEDEFQVQGVLFYDCPEGVMEERLLERGKTSGRTDDNAEAIRKRFRTYLDSTMPVIMHYEKQNKVFKVDATPGPDEVFEATAALIGPLVADK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAENGY010000589
EMBL· GenBank· DDBJ
KAG6959928.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp