A0A8J4T9C9 · A0A8J4T9C9_9BACT

Function

function

Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

135550100150200250300350
TypeIDPosition(s)Description
Binding site36-41ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionligase activity, forming carbon-nitrogen bonds
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA(Ile)-lysidine synthase
  • EC number
  • Alternative names
    • tRNA(Ile)-2-lysyl-cytidine synthase
    • tRNA(Ile)-lysidine synthetase

Gene names

    • Name
      tilS
    • ORF names
      Udaeo2_19100

Organism names

  • Taxonomic identifier
  • Strain
    • AEW3
  • Taxonomic lineage
    Bacteria > Verrucomicrobiota > Spartobacteria > Chthoniobacterales > Chthoniobacteraceae > Candidatus Udaeobacter

Accessions

  • Primary accession
    A0A8J4T9C9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-87tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Domain114-244tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Domain288-352tRNA(Ile)-lysidine synthase substrate-binding

Domain

The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

Sequence similarities

Belongs to the tRNA(Ile)-lysidine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    40,445
  • Last updated
    2022-05-25 v1
  • Checksum
    10AF0E0B8A9385FA
MIALNVGCSGAMNWIQTETNLLRTFPLDGRYLIGVSGGRDSVVLLHWLISVGYKNLMVCHLNHLLRGRSSDADARFVQKRVEHYDHEFVEHAPSLPGSRTGKRSARPTTRRPGLHFELGTLDVRAFATKQKMSIEAAARDSRYSFFAKVAKRRRCHTIFLAHHADDLVETFLINLFRGAGSAGLAAMREVSTRCIDDVGLTIVRPLLGVWRKEIDNYVRKHRLTFREDASNKNLNPLRNRIRHRVIPYLEKILGRNIRPAIWRAATIAGEEEAWMDGQLPDSSYIEISVATLRELPVALQRRAILKWLRAQKVSEVGFDVIERVRLLIDPTGQVAKVNLAHNRHARRRSGKIFIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAALOD010000046
EMBL· GenBank· DDBJ
KAF5407930.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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