A0A8J2Z7L4 · A0A8J2Z7L4_9PROT

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site99-101substrate
Binding site130-133substrate; in site B
Binding site140-142substrate
Binding site188substrate
Active site189Proton donor/acceptor
Active site319
Binding site320substrate
Binding site325-327substrate
Site332Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC1
    • Synonyms
      fumC
    • ORF names
      GCM10010964_00840

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CGMCC 1.16330
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Caldovatus

Accessions

  • Primary accession
    A0A8J2Z7L4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-343Fumarate lyase N-terminal
Domain409-461Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    471
  • Mass (Da)
    50,637
  • Last updated
    2022-05-25 v1
  • Checksum
    182EC645DD1D9813
MAEPTRTETDSLGSIEIPAERYWGPQTERARRLFRIGSERFPAALIRAVGLHKWACAEANRRLGQLPDAIAEAIKQAALEIAEGRRDEDFPLPVWQTGSGTQTNMNANEVIANRANEILGRPLGAREPVHPNDHVNRGQSSNDNFPTMMHMAAAEVVEGRLLPALGRLHAALWRRSEEWAGIVKVGRTHLMDAVPVTLGQEFGTWARQVELGMARLRDAMPRLLLLPQGGTAVGTGLNRHPDFDRVFCEIVAGRTGLAFAPSPDKSEGMAAHDVFVELHGAMNVIAVSLNKVANDIRLLGSGPRCGIGELVIPADGLSSSIMPGKTNPTQAEALTMVCAQVMGNTVTVTVAGAQGHLELNVFKPVIIHAVLQSATLLADAAESFAANMVDKLEPNRARIAENLAKSLMLVTALNPRIGYDKAVAIAKKALAEDLTLKEAAARLGHVSPEDFDRWVRPEDMVAPGATLEGGG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BMKS01000001
EMBL· GenBank· DDBJ
GGG16380.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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