A0A8J2Z7H7 · A0A8J2Z7H7_9PROT

  • Protein
    GTP 3',8-cyclase
  • Gene
    moaA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50GTP (UniProtKB | ChEBI)
Binding site57[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site61[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site63S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site64[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site99GTP (UniProtKB | ChEBI)
Binding site103S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site133GTP (UniProtKB | ChEBI)
Binding site157S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site193GTP (UniProtKB | ChEBI)
Binding site227S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site290[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site293[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site295-297GTP (UniProtKB | ChEBI)
Binding site307[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclic pyranopterin monophosphate synthase activity
Molecular FunctionGTP 3',8'-cyclase activity
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological ProcessMo-molybdopterin cofactor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP 3',8-cyclase
  • EC number
  • Alternative names
    • Molybdenum cofactor biosynthesis protein A

Gene names

    • Name
      moaA
    • ORF names
      GCM10010964_00240

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CGMCC 1.16330
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Caldovatus

Accessions

  • Primary accession
    A0A8J2Z7H7

Proteomes

Interaction

Subunit

Monomer and homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain41-267Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    40,177
  • Last updated
    2022-05-25 v1
  • Checksum
    78C6DC8C53506FCB
MRAGMGGSQIPSAMSADIRLPPAAAASAADASGAAAPLVDPFGRRITYLRVSVTDRCDLRCVYCMAEDMTFLPKAEVLTLEELDRLCGAFIRLGVEKIRLTGGEPLVRKNVISLVRALGARLGAGGLRELTVTTNGTQLARLADGLRAAGVRRINVSLDTLDPAKFTAITRWGRIEQTLDGIFAARAAGLAVKINAVALKGVNEDEFDRMIAWCGEHGFDLCLIETMPLGEISGDRTEQYLPLSLVRARLRQRWTLEETDYRTGGPARYYVVRETGRRIGFITPLTHNFCESCNRVRLTCTGTLYMCLGQEDAADLRRPLRDPGTDEAGLEAAIREAIARKPRGHDFVIDRRHRRPALARHMSVTGG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BMKS01000001
EMBL· GenBank· DDBJ
GGG15877.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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