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A0A8J2WSK8 · A0A8J2WSK8_9STRA

Function

function

Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site39-44NADP+ (UniProtKB | ChEBI)
Binding site125NADPH (UniProtKB | ChEBI)
Binding site149NADPH (UniProtKB | ChEBI)
Binding site236L-homoserine (UniProtKB | ChEBI)
Active site251Proton donor

GO annotations

AspectTerm
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processmethionine biosynthetic process
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoserine dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • ORF names
      PECAL_1P02040

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Ochrophyta > Pelagophyceae > Pelagomonadales > Pelagomonadaceae > Pelagomonas

Accessions

  • Primary accession
    A0A8J2WSK8

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503531299919-382Homoserine dehydrogenase

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-163Aspartate/homoserine dehydrogenase NAD-binding
Domain183-378Homoserine dehydrogenase catalytic

Sequence similarities

Belongs to the homoserine dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    39,585
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    32D22811E355B8520860BB0DE34C65B7
MHRLLCALLLTTAAAVDTDKTCASDDCMAAKQVPVALLGVGGVGRALVEALVGARTHHKDVYGLRFDVKVLADSSGYLAGDLDDAQLQSAAAAKADGKKLPGATKGDVDKAVASLGEGALVVDVTASGSTTPLLIEALKRGQKVVSANKKPFSSDQAAYDALVGHPIRHNNVRHESTVGAGLPAIAALNRLSMADDKVRKIAGTFSGTLGFVMSGLEAGRPFSEVVLEAKAKGYTEPDPRDDLGGVDVARKALILARGLGWRLELSDVNVEPLYPPEMASLTVDDFMAKLPSLDEDFAKRAKEAKARGEALRYAATVEDGRLTVGLVSVSTSSPLGSLSGTDNLVEYYTTWYDPSPLVVRGAGAGAGATAAGALADMVELSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAKKNE010000001
EMBL· GenBank· DDBJ
CAH0363865.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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