A0A8J2WSK8 · A0A8J2WSK8_9STRA
- ProteinHomoserine dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids382 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Catalytic activity
- L-homoserine + NADP+ = L-aspartate 4-semialdehyde + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 39-44 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 125 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 149 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 236 | L-homoserine (UniProtKB | ChEBI) | |||
Active site | 251 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | methionine biosynthetic process | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Ochrophyta > Pelagophyceae > Pelagomonadales > Pelagomonadaceae > Pelagomonas
Accessions
- Primary accessionA0A8J2WSK8
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5035312999 | 19-382 | Homoserine dehydrogenase | ||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 39-163 | Aspartate/homoserine dehydrogenase NAD-binding | |||
Domain | 183-378 | Homoserine dehydrogenase catalytic | |||
Sequence similarities
Belongs to the homoserine dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length382
- Mass (Da)39,585
- Last updated2022-05-25 v1
- MD5 Checksum32D22811E355B8520860BB0DE34C65B7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAKKNE010000001 EMBL· GenBank· DDBJ | CAH0363865.1 EMBL· GenBank· DDBJ | Genomic DNA |