A0A8J1TU13 · A0A8J1TU13_OWEFU

Function

function

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site36-55NAD+ (UniProtKB | ChEBI)
Binding site80substrate
Binding site83substrate
Binding site118-121NAD+ (UniProtKB | ChEBI)
Active site136Proton acceptor
Binding site144Zn2+ (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)
Binding site185Zn2+ (UniProtKB | ChEBI)
Binding site190Zn2+ (UniProtKB | ChEBI)
Binding site227-229NAD+ (UniProtKB | ChEBI)
Binding site253-255NAD+ (UniProtKB | ChEBI)
Binding site271NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog 5

Gene names

    • ORF names
      OFUS_LOCUS6145

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Polychaeta > Sedentaria > Canalipalpata > Sabellida > Oweniida > Oweniidae > Owenia

Accessions

  • Primary accession
    A0A8J1TU13

Proteomes

Subcellular Location

Keywords

Family & Domains

Domain

In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-80 and Arg-83) that bind to malonylated and succinylated substrates and define the specificity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    54,044
  • Last updated
    2022-05-25 v1
  • Checksum
    0D245378FD6F6F58
MASSAKRPRRHVRPSSNMAKFREHFAKAKHIVLLTGAGVSAESGVPTFRGAGGLWRKYQATDLATPEAFAANPSLLWEFYHYRRNSMLDKRPNDAHKAIAECEARLEKQERRVVIITQNIDELHAKAGSKNIIELHGNLFKVRCTKCGRIDYTRSRVLCPALEGKGEPDPKAKDARIPVEDLPKCSDPDCRGLIRPHVVWFGEDLDEDIFKRAEEELEQCDLCLLVGTSSVVYPAAMFAPNVAARGVPVAEFNMEDTKVSGHFGFHFSGPAGVTIPIALAEHKNEIIAQVESEPLSNAQLPDSEESVSNHSNDTSVSGSTIDSTGFDFPRGKEESESTRTKMESDSTQVKTESGSPHVKLESDTSHVKTESDDRIKESEITQVKMESDSHIKTESPYDKTQSDISDGKTNSNSPNLAESDSTNDQSEKNTPNEPYKIGTGENDLTATEIVDHPSGQTYEPENEVSNPKGIDTHGEIVNDSTEPPVSDTNQQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIIXF020000003
EMBL· GenBank· DDBJ
CAH1779326.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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