A0A8J0PPU8 · A0A8J0PPU8_XENLA

Function

function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenteukaryotic 43S preinitiation complex
Cellular Componenteukaryotic 48S preinitiation complex
Cellular Componenteukaryotic translation initiation factor 3 complex
Molecular FunctionRNA binding
Molecular Functiontranslation initiation factor activity
Biological Processformation of cytoplasmic translation initiation complex

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Eukaryotic translation initiation factor 3 subunit A
  • Short names
    eIF3a
  • Alternative names
    • Eukaryotic translation initiation factor 3 subunit 10
    • eIF-3-theta

Gene names

    • Name
      eif3a.L
    • Synonyms
      eif3
      , eIF3-p170
      , eif3-theta
      , EIF3A
      , eif3a
      , EIF3S10
      , eif3s10
      , ncl
      , Nucleolin
      , tif32

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A8J0PPU8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine.

TypeIDPosition(s)Description
Initiator methionine1Removed

Interaction

Subunit

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Domain315-498PCI
Coiled coil565-634
Coiled coil670-701
Compositional bias811-913Basic and acidic residues
Region811-1370Disordered
Compositional bias920-1208Basic and acidic residues
Compositional bias1220-1370Basic and acidic residues

Sequence similarities

Belongs to the eIF-3 subunit A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,370
  • Mass (Da)
    162,297
  • Last updated
    2022-05-25 v1
  • Checksum
    8B10BC569E6FBB1C
MPVYFQRPENALKRANEFLEVGKKQPALDVLYDVIKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEERTESAKESSQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSKVERLYHDIAQQAFKFCLLYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFALSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQSPPNRAGLIKDMVRFNVMQYILPEVKELYNWLEVDFHPLKLCDRVTKVLDWIKEQAEKEPELQQYVPQLQSNTVLRLLQQVAQIYQTIEFSRLASLLPFVDAFLLERAIVDAARHCNLQVRIDHTSRTLSFGSDLNYSTREDAPVGPFLQNMPSEHIRNQLTAMSSVLSKAVATIKPAHVLQEKEEQHQIAIVSYQKNSRKEHQRILARRQTIEERKERLENLNIQREKEEHEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTEFGAKAFKDIDIENLEELDPDFIMAKQVEQLEKEKRELQDRLKNQEKKIDYFERAKRLEEIPPLKKAYDEQRISDMELWEQQEEERISTLLLEREKAVEHKNRMSRMLEDKESFVSELKASRQSVFEAKLKQFQERLAEEKHARLEERKRQRKEERRIAYYRDKEEEEQRLKEEQLKQEQEEREKIENEKREAEQREYQERIKKLEEQERKKRQRELEIEERERKREEERRGGDDTLRKDTSRWGEREESGWRRGEEPDERKQAPPESIWRRAGQDSKPVRDEDHEADEDASLRKDEEQVSRPDGEEEKGGSWRGTDDRGPKRGLEEDRGPRRGFEDDRGPRRGLDDDRGPRRGLDDDRVPRRGLDDDRGPRRGIDDDRAPRRGFDEDRGPRRGIDDDSGPRRGFDDDRGPRRGFDDDRGPRRGFDDDRGPRRGFDDDRGPRRGFDDDRGPRRGFEDDRVPRRGFEDDRGPRRGFEEDRGPRRGFDEDRGPRRGFEDDRAPRRGFDEDRTPSRGFDDDRGSWRGAADEDRGPRRGAADEDRGPRRGADEDRGPRRGADEDRGQTPWKPIVASRPGGWREREKAREDSWGPPHESKPAEERSWAKRGEESEKDSERDKHPVREESVWRRGGDDNVTPRKVSPGDKSTDDKTEPRDRRRVPPKTDEASPWRRDEEKESRQEERGTPRGAPAVDREKPSWNTEKEEKDAPRRTKLETDEDGWTTVRR

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L8FIA3A0A1L8FIA3_XENLAeif3a.L1390
A0A8J1L424A0A8J1L424_XENLAeif3a.L1359
A0A8J1L5S4A0A8J1L5S4_XENLAeif3a.L1380
A0A8J1L6T2A0A8J1L6T2_XENLAeif3a.L1379

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias811-913Basic and acidic residues
Compositional bias920-1208Basic and acidic residues
Compositional bias1220-1370Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp