A0A8I6GH61 · A0A8I6GH61_RAT
- ProteinLDL receptor related protein 8
- GeneLrp8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids873 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6GH61
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 735-758 | Helical | ||||
Sequence: AAVIGIIVPIVVIALLCMSGYLIW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: MGRPERGALRPLALLLLLLLLLLQLQHLSTA | ||||||
Chain | PRO_5035303937 | 32-873 | ||||
Sequence: DPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP | ||||||
Disulfide bond | 44↔56 | |||||
Sequence: CEEDQFRCRNERC | ||||||
Disulfide bond | 51↔69 | |||||
Sequence: CRNERCIPSVWRCDEDNDC | ||||||
Disulfide bond | 63↔78 | |||||
Sequence: CDEDNDCSDNSDEDDC | ||||||
Disulfide bond | 83↔95 | |||||
Sequence: CTDSDFTCDNGHC | ||||||
Disulfide bond | 90↔108 | |||||
Sequence: CDNGHCIPERWKCDGEEEC | ||||||
Disulfide bond | 145↔160 | |||||
Sequence: CDGEKDCEGGADEAGC | ||||||
Disulfide bond | 168↔180 | |||||
Sequence: CRENDFQCGDGTC | ||||||
Disulfide bond | 175↔193 | |||||
Sequence: CGDGTCILAIKRCNQERDC | ||||||
Disulfide bond | 187↔202 | |||||
Sequence: CNQERDCLDGSDEAGC | ||||||
Disulfide bond | 216↔234 | |||||
Sequence: CKSGECVDGGKVCDDQRDC | ||||||
Disulfide bond | 290↔300 | |||||
Sequence: CQDPDACSQIC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 286-325 | EGF-like | ||||
Sequence: DIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCK | ||||||
Repeat | 372-418 | LDL-receptor class B | ||||
Sequence: NRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVH | ||||||
Repeat | 419-461 | LDL-receptor class B | ||||
Sequence: KHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLR | ||||||
Repeat | 462-505 | LDL-receptor class B | ||||
Sequence: GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLS | ||||||
Repeat | 506-550 | LDL-receptor class B | ||||
Sequence: QRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDK | ||||||
Region | 665-728 | Disordered | ||||
Sequence: PATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQ |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length873
- Mass (Da)96,766
- Last updated2022-05-25 v1
- Checksum67302E6EBC7588C0
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5ZTA7 | A0A8I5ZTA7_RAT | Lrp8 | 958 | ||
A0A8I6ALZ7 | A0A8I6ALZ7_RAT | Lrp8 | 972 | ||
D3ZE75 | D3ZE75_RAT | Lrp8 | 999 | ||
A0A8I6AE51 | A0A8I6AE51_RAT | Lrp8 | 697 | ||
A0A8I6GFL9 | A0A8I6GFL9_RAT | Lrp8 | 913 | ||
A0A8I6A6L0 | A0A8I6A6L0_RAT | Lrp8 | 729 | ||
A0A8I5ZVL7 | A0A8I5ZVL7_RAT | Lrp8 | 790 |
Keywords
- Technical term