In thyroid FRTL-5 cells activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2 thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I.
COMMD1 modulates Na(+) transport in epithelial cells through regulation of ENaC cell surface expression and this effect is likely mediated via Nedd4-2.
Nedd4-mediated ubiquitination of Cx43 is required to recruit Eps15 through its ubiquitin-interacting motif and targets ubiquitinated Cx43 to the endocytic pathway.
-2 is potentially an important regulator of M-current activity in the nervous system and voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination
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