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A0A8I6G788 · A0A8I6G788_RAT

  • Protein
    E3 ubiquitin-protein ligase
  • Gene
    Dtx3l
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentearly endosome
Cellular Componentlysosome
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular Functionhistone binding
Molecular Functionhistone H4K91 ubiquitin ligase activity
Molecular Functionhistone ubiquitin ligase activity
Molecular Functionmetal ion binding
Molecular Functionprotein ADP-ribosyltransferase-substrate adaptor activity
Molecular FunctionSTAT family protein binding
Molecular Functionubiquitin-like protein ligase binding
Molecular Functionubiquitin-protein transferase activity
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processdouble-strand break repair
Biological Processendosome to lysosome transport
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of defense response to virus by host
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of protein localization to early endosome
Biological Processpositive regulation of protein localization to nucleus
Biological Processpositive regulation of receptor catabolic process
Biological Processprotein autoubiquitination
Biological Processprotein K48-linked ubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • Name
      Dtx3l

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6G788

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region35-67Disordered
Domain519-557RING-type

Sequence similarities

Belongs to the Deltex family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    698
  • Mass (Da)
    77,654
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    F5DAF03946722F1FE9E7AD4E3604311C
MYVFNVSPQDKENVLKRGKHKLLVDDKSVPIVLETIKKPEEDLRPRPPSLTQPAETPSSRPPSLTESLDEALGDKIPSDGPVFNSVDSVVQKVFLAVTAELNCELLSKEQRAQITAVCPHIKSMEGSDGIKKVCGNFKDIEKIHHFLSSQLLESEPTRKYVPQKYTPSDVEREPPSQRSFEVSVLFLEYFKHIYPGRIESIEKKFGVNIKIQDSSPYMVSIGFTSRQSGNLEEACQSFVRDFQKCTQSLKQDCISLEDQQRAKKVRQELSRCFPKLLIKEQGRMLTLLGSAADIAAAAEKVSQTLVPAPVKIVATPVKIATPVKIATSGYMTGIEVDSTRFKLLEPELLQEIAEIEQKFNTCGKVQEKGQKTCILFVPKDKELDLSVQSYTSFTEAFQHATCQLRTEVLSLKQLGKEKAQLHKTKFADDFKIKHPNVHFVISQESVTLTGLPNHLGQAMQYVAKRIGMPTLLSSGEKLAMDHETPMEVHRNDSDVALLSFGSSASSPTASKGNKDEDNCVICMDTIRNKQVLPKCKHEFCSSCISKAMSFKPVCPVCLTPYGVQKGNQPEGTMAHTIQKDSLPGYEGCGTIVIQYSFGDGIQTKEHPNPGKAYSGTCRVAYLPDNAEGRKVLHLLRKAFDQKLIFTVGESRVLGISNVITWNDIHHKTAKFGGPSNFGYPDPDYLKRVKEELKSKGIE

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z8X6D3Z8X6_RATDtx3l750

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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