A0A8I6ASB4 · A0A8I6ASB4_RAT

Function

function

DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

156650100150200250300350400450500550
TypeIDPosition(s)Description
Active site303Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase
  • EC number

Gene names

    • Name
      Poll

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6ASB4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain35-131BRCT
Region159-228Disordered
Compositional bias177-205Polar residues

Sequence similarities

Belongs to the DNA polymerase type-X family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    566
  • Mass (Da)
    61,643
  • Last updated
    2022-05-25 v1
  • Checksum
    265384407284B51B
MDPQGILKAFPKRKKIHADPSSNALAKIPKREAGDARGWLSSLRAHIMPTGIGRARAELFEKQIIQHGGQVCSAQAPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQEKKLTDTDGFSLSSPKRSAALSLSQTFDILTACDLPLKSGQDASAPAVSPPPKAEKPPKTQTQLSSEDEASDGEGPQVSSADLQALISGHYPTPPGEDGGPDPAPEALGKWVCAQPSSQKATNYNLHITEKLEVLAKAYNVQGDKWRALGYAKAINALKSFHKPVSSYQEACSIPGVGRRMAEKVMEILESGHLRKLDHISDSVPVLELFSNIWGAGTKTAQMWYHQGFRSLEDIRGLASLTAQQAIGLKHYDDFLDRMPREEAAEIEQMVRVSAQAFNPGLLCVACGSFRRGKVTCGDVDVLITHPDGRSHQGIFSPLLDSLRQQGFLTDDLVSQEENGQQQKYLGVCRLPGAGQRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSAAVVRNSQGVKVGAGQVLPTPTEKDVFKLLGLPYREPAERDW

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q5RKI3DPOLL_RATPoll573

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias177-205Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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