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A0A8I6AJC6 · A0A8I6AJC6_RAT

  • Protein
    RAS guanyl releasing protein 4
  • Gene
    Rasgrp4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentcytosol
Cellular Componentnucleoplasm
Molecular Functioncalcium ion binding
Molecular Functiondiacylglycerol binding
Molecular Functionguanyl-nucleotide exchange factor activity
Biological Processantibacterial innate immune response
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of natural killer cell mediated immunity
Biological Processsmall GTPase-mediated signal transduction

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • RAS guanyl releasing protein 4

Gene names

    • Name
      Rasgrp4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6AJC6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-33Disordered
Domain49-181N-terminal Ras-GEF
Domain190-421Ras-GEF
Domain455-490EF-hand
Domain529-584Phorbol-ester/DAG-type
Region587-608Disordered
Compositional bias593-607Pro residues

Sequence similarities

Belongs to the RASGRP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    703
  • Mass (Da)
    78,843
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    0BF411FDDD3DAFD5B10B256F1C779345
KNRGEAKYYSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLTLKYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEANPTLLPWPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVRRWIWERQAVYLGKPDGYGHHRKVKSCKKPQSPGWGGRGIVYPGMLSVTGVKH

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8R5I4GRP4_RATRasgrp4678
F1LMG1F1LMG1_RATRasgrp4679
A0A8I6A7B4A0A8I6A7B4_RATRasgrp4581
A0A8I5ZLP3A0A8I5ZLP3_RATRasgrp4576
A0A8I5ZWG4A0A8I5ZWG4_RATRasgrp4484

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias593-607Pro residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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