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A0A8I6AIY8 · A0A8I6AIY8_RAT

  • Protein
    Fructose-2,6-bisphosphatase TIGAR
  • Gene
    Tigar
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

126820406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site10-17substrate
Active site11Tele-phosphohistidine intermediate
Binding site61substrate
Active site89Proton donor/acceptor
Binding site89-92substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionfructose-2,6-bisphosphate 2-phosphatase activity
Biological Processcardiac muscle cell apoptotic process
Biological Processcellular response to cobalt ion
Biological Processcellular response to hypoxia
Biological ProcessDNA damage response
Biological Processfructose 2,6-bisphosphate metabolic process
Biological Processglucose catabolic process to lactate via pyruvate
Biological Processglycolytic process
Biological Processintestinal epithelial cell development
Biological Processmitophagy
Biological Processnegative regulation of glucose catabolic process to lactate via pyruvate
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of mitophagy
Biological Processnegative regulation of programmed cell death
Biological Processnegative regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of cardiac muscle cell apoptotic process
Biological Processpositive regulation of DNA repair
Biological Processpositive regulation of pentose-phosphate shunt
Biological Processreactive oxygen species metabolic process
Biological Processregulation of pentose-phosphate shunt
Biological Processregulation of response to DNA damage checkpoint signaling
Biological Processresponse to gamma radiation
Biological Processresponse to ischemia
Biological Processresponse to xenobiotic stimulus

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-2,6-bisphosphatase TIGAR
  • EC number
  • Alternative names
    • TP53-induced glycolysis and apoptosis regulator

Gene names

    • Name
      Tigar

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6AIY8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the phosphoglycerate mutase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    268
  • Mass (Da)
    29,477
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    F6EADEF8455530B41C2E22DFF8B32709
MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQTIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K8S8A0A0G2K8S8_RATTigar269
A0A8I6A9E3A0A8I6A9E3_RATTigar197
A0A8I6A442A0A8I6A442_RATTigar176

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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