A0A8I6AIK2 · A0A8I6AIK2_RAT
- Proteinreceptor protein-tyrosine kinase
- GeneEphb4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids935 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 621-629 | ATP (UniProtKB | ChEBI) | |||
Binding site | 647 | ATP (UniProtKB | ChEBI) | |||
Active site | 740 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | ephrin receptor activity | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | angiogenesis | |
Biological Process | cell adhesion | |
Biological Process | cell migration involved in sprouting angiogenesis | |
Biological Process | ephrin receptor signaling pathway | |
Biological Process | heart morphogenesis | |
Biological Process | positive regulation of aorta morphogenesis | |
Biological Process | positive regulation of T cell costimulation | |
Biological Process | protein phosphorylation | |
Biological Process | venous blood vessel morphogenesis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6AIK2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 538-563 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-15 | ||||
Chain | PRO_5035292276 | 16-935 | receptor protein-tyrosine kinase | ||
Disulfide bond | 61↔184 | ||||
Disulfide bond | 97↔107 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 17-202 | Eph LBD | |||
Domain | 323-432 | Fibronectin type-III | |||
Domain | 436-529 | Fibronectin type-III | |||
Domain | 615-878 | Protein kinase | |||
Domain | 857-919 | SAM | |||
Region | 915-935 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length935
- Mass (Da)103,029
- Last updated2022-05-25 v1
- MD5 Checksum3A9AAE7331AD287F3CE8074F8FA75342
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6GKB3 | A0A8I6GKB3_RAT | Ephb4 | 986 | ||
M0RDA4 | M0RDA4_RAT | Ephb4 | 996 |
Keywords
- Technical term