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A0A8I6AIK2 · A0A8I6AIK2_RAT

Function

Catalytic activity

Features

Showing features for binding site, active site.

1935100200300400500600700800900
Type
IDPosition(s)Description
Binding site621-629ATP (UniProtKB | ChEBI)
Binding site647ATP (UniProtKB | ChEBI)
Active site740Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionephrin receptor activity
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological Processangiogenesis
Biological Processcell adhesion
Biological Processcell migration involved in sprouting angiogenesis
Biological Processephrin receptor signaling pathway
Biological Processheart morphogenesis
Biological Processpositive regulation of aorta morphogenesis
Biological Processpositive regulation of T cell costimulation
Biological Processprotein phosphorylation
Biological Processvenous blood vessel morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      Ephb4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6AIK2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane538-563Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_503529227616-935receptor protein-tyrosine kinase
Disulfide bond61↔184
Disulfide bond97↔107

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain17-202Eph LBD
Domain323-432Fibronectin type-III
Domain436-529Fibronectin type-III
Domain615-878Protein kinase
Domain857-919SAM
Region915-935Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    935
  • Mass (Da)
    103,029
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    3A9AAE7331AD287F3CE8074F8FA75342
MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSRLVTNLTYFPETVPRELVVPVAGSCVANAVPTASPSPSLYCREDGQWAEQQVTGCSCAPGYEAAEGNKVCRACGQGTFKPQIGEEPCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSSLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDLTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKQGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVIIIAVLCLRKQSSGREVEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGDLLRIGVTLAGHQKKILASVQHMKSQAKPGAPGGTGGPTQQF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GKB3A0A8I6GKB3_RATEphb4986
M0RDA4M0RDA4_RATEphb4996

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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