A0A8I6AEN2 · A0A8I6AEN2_RAT

  • Protein
    receptor protein-tyrosine kinase
  • Gene
    Csf1r
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for binding site, active site, site.

110201002003004005006007008009001,000
Type
IDPosition(s)Description
Binding site601Mg2+ (UniProtKB | ChEBI)
Binding site628-636ATP (UniProtKB | ChEBI)
Binding site629-636ATP (UniProtKB | ChEBI)
Binding site656ATP (UniProtKB | ChEBI)
Binding site704-710ATP (UniProtKB | ChEBI)
Active site818Proton acceptor
Binding site822ATP (UniProtKB | ChEBI)
Binding site823Mg2+ (UniProtKB | ChEBI)
Binding site836Mg2+ (UniProtKB | ChEBI)
Site963Important for interaction with phosphotyrosine-binding proteins

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioncytokine binding
Molecular Functionmetal ion binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological Processanimal organ development
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processcytokine-mediated signaling pathway
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      Csf1r

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6AEN2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane553-578Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond84↔126
Disulfide bond169↔219
Disulfide bond266↔320
Disulfide bond459↔525

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain63-127Ig-like
Domain149-230Ig-like
Domain245-336Ig-like
Domain442-542Ig-like
Domain622-956Protein kinase
Region962-1000Disordered
Compositional bias963-990Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,020
  • Mass (Da)
    114,068
  • Last updated
    2022-05-25 v1
  • Checksum
    7E9927042BD2508D
MSGWDHGGFCGSWNGVVSLRVTHTHTHTHTHTHTHRGEVTTEIVLMGQRSTDVQRVNDCQGAPVIEPSGPELVVEPGATVTLRCVSNGSVEWDGPISPYWTLDSESPGSILITKNATFKNTGTYRCTELEDPMRGSTAIHLYVKDPVRPWNLLAQEVTVFEGQEAVLPCLITDPTLKDSVSLVREWGRPVSRKTVYSFLPWRGFIIHKAKFLDSHTYMCKAVVNARESTSIGIRLKVNRAHPGPPHIILEPTKLVRIRGEAAQIVCSATHSEVEFNVILKRGDTKLEIPINSDFQDNAYKKVLTLNLNAVDFQDAGIYSCVANNAAGSNTATMNFQVVESAYLNLTSEQSLLQEVSVGENLDLTVIADAYPGLQRYNWTYLGPFFEDPHNLEFRTQWTTYSYSFKLHLNRVKPLEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTWIPVNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDDTQPEVLSQKPFHRVILQSQLPIGTLKHNMTYVCRAHNNVGNSSQFFRAISLGQSKQLPDEYLFTPVVVACISVMSLLVLLLLLLLYKYKQKPKYQVRWKIIESYEGNNYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICFLLQEQARLERREQDYANLPSSSSSSSSSSDSGGGSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFC

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q00495CSF1R_RATCsf1r978
A0A0G2K3Y5A0A0G2K3Y5_RATCsf1r450
A0A0G2KBC4A0A0G2KBC4_RATCsf1r980
A0A8I5ZZ98A0A8I5ZZ98_RATCsf1r978
D4ACA7D4ACA7_RATCsf1r1022
A0A8I6A5F0A0A8I6A5F0_RATCsf1r479
A0A8I5ZP95A0A8I5ZP95_RATCsf1r968

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias963-990Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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