A0A8I6AEN2 · A0A8I6AEN2_RAT
- Proteinreceptor protein-tyrosine kinase
- GeneCsf1r
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1020 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 601 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 628-636 | ATP (UniProtKB | ChEBI) | |||
Binding site | 629-636 | ATP (UniProtKB | ChEBI) | |||
Binding site | 656 | ATP (UniProtKB | ChEBI) | |||
Binding site | 704-710 | ATP (UniProtKB | ChEBI) | |||
Active site | 818 | Proton acceptor | |||
Binding site | 822 | ATP (UniProtKB | ChEBI) | |||
Binding site | 823 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 836 | Mg2+ (UniProtKB | ChEBI) | |||
Site | 963 | Important for interaction with phosphotyrosine-binding proteins | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | cytokine binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | animal organ development | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | cytokine-mediated signaling pathway | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6AEN2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 553-578 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 84↔126 | ||||
Disulfide bond | 169↔219 | ||||
Disulfide bond | 266↔320 | ||||
Disulfide bond | 459↔525 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 63-127 | Ig-like | |||
Domain | 149-230 | Ig-like | |||
Domain | 245-336 | Ig-like | |||
Domain | 442-542 | Ig-like | |||
Domain | 622-956 | Protein kinase | |||
Region | 962-1000 | Disordered | |||
Compositional bias | 963-990 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,020
- Mass (Da)114,068
- Last updated2022-05-25 v1
- Checksum7E9927042BD2508D
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q00495 | CSF1R_RAT | Csf1r | 978 | ||
A0A0G2K3Y5 | A0A0G2K3Y5_RAT | Csf1r | 450 | ||
A0A0G2KBC4 | A0A0G2KBC4_RAT | Csf1r | 980 | ||
A0A8I5ZZ98 | A0A8I5ZZ98_RAT | Csf1r | 978 | ||
D4ACA7 | D4ACA7_RAT | Csf1r | 1022 | ||
A0A8I6A5F0 | A0A8I6A5F0_RAT | Csf1r | 479 | ||
A0A8I5ZP95 | A0A8I5ZP95_RAT | Csf1r | 968 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 963-990 | Polar residues | |||
Keywords
- Technical term