A0A8I6A605 · A0A8I6A605_RAT
- ProteinRegulator of telomere elongation helicase 1
- GeneRtel1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1178 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | metal ion binding | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | regulation of double-strand break repair via homologous recombination | |
Biological Process | telomere maintenance |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRegulator of telomere elongation helicase 1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6A605
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with PCNA within the replication foci in S-phase cells.
Keywords
- Cellular component
Interaction
Subunit
Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex.
Structure
Family & Domains
Features
Showing features for domain, motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-296 | Helicase ATP-binding | ||||
Sequence: NGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCTTLAWREHLRDAVSSLKIAERVQGELFASRTLSSWRSAADANGDSIDCYTDIPKIIYASRTHSQLTQVIGELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEEKSLEQELATPILDIEDLVKNGSKHKVCPYYLSRNLKQQADIIFMPYNYLLDAKSRKAHNIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEVINQVLEEQARVAQHGELQ | ||||||
Motif | 151-167 | Nuclear localization signal | ||||
Sequence: KKQESNHMQISLCRKKV | ||||||
Region | 1098-1178 | Disordered | ||||
Sequence: KGLELPCPRDESTTVPSELTHEDMKPGPSTSKKPEKTQSKISSFLRQRPDQSARSDDTIMQLPPRLPPEHTTSQWSKQQGL | ||||||
Compositional bias | 1128-1155 | Polar residues | ||||
Sequence: SKKPEKTQSKISSFLRQRPDQSARSDDT | ||||||
Compositional bias | 1164-1178 | Polar residues | ||||
Sequence: PPEHTTSQWSKQQGL |
Sequence similarities
Belongs to the helicase family. RAD3/XPD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,178
- Mass (Da)131,070
- Last updated2022-05-25 v1
- ChecksumB520D183B3530456
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5RJZ1 | RTEL1_RAT | Rtel1 | 1274 | ||
A0A8I6AMG5 | A0A8I6AMG5_RAT | Rtel1 | 1262 | ||
A0A0G2JVG0 | A0A0G2JVG0_RAT | Rtel1 | 1220 | ||
A0A8I6A8F3 | A0A8I6A8F3_RAT | Rtel1 | 1217 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1128-1155 | Polar residues | ||||
Sequence: SKKPEKTQSKISSFLRQRPDQSARSDDT | ||||||
Compositional bias | 1164-1178 | Polar residues | ||||
Sequence: PPEHTTSQWSKQQGL |
Keywords
- Technical term