A0A8I6A5T3 · A0A8I6A5T3_RAT
- Protein[histone H3]-trimethyl-L-lysine(27) demethylase
- GeneKdm6a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1452 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- 2 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N6-methyl-L-lysyl27-[histone H3] + 2 succinate
2 CHEBI:16810 + RHEA-COMP:15535 CHEBI:61961 Position: 27+ 2 CHEBI:15379 = 2 CHEBI:16526 + 2 CHEBI:16842 + RHEA-COMP:15544 CHEBI:61929 Position: 27+ 2 CHEBI:30031
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-trimethyl-L-lysine(27) demethylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6A5T3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 129-162 | TPR | ||||
Sequence: AAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSF | ||||||
Repeat | 204-237 | TPR | ||||
Sequence: AEIQFHIAHLYETQRKYHSAKEAYEQLLQLENLS | ||||||
Repeat | 317-350 | TPR | ||||
Sequence: ADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGH | ||||||
Region | 469-515 | Disordered | ||||
Sequence: LHMIPPSQVDDLSSPAKRKRTSSPTKNTSDNWSGGNAVPHPPVQQQT | ||||||
Compositional bias | 486-515 | Polar residues | ||||
Sequence: RKRTSSPTKNTSDNWSGGNAVPHPPVQQQT | ||||||
Compositional bias | 564-610 | Polar residues | ||||
Sequence: TGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQ | ||||||
Region | 564-617 | Disordered | ||||
Sequence: TGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQPACPRQA | ||||||
Region | 647-796 | Disordered | ||||
Sequence: NHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGQSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTLPETNRQTGETPNSTASVE | ||||||
Compositional bias | 861-913 | Polar residues | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEES | ||||||
Region | 861-914 | Disordered | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQ | ||||||
Region | 965-992 | Disordered | ||||
Sequence: LLDKCPPPRPPSSPYPPLPKDKLNPPTP | ||||||
Compositional bias | 968-988 | Pro residues | ||||
Sequence: KCPPPRPPSSPYPPLPKDKLN | ||||||
Region | 1094-1130 | Disordered | ||||
Sequence: FQESLREENEKRSHHKDHSDSESTSSDNSGKRRRGPF | ||||||
Compositional bias | 1097-1127 | Basic and acidic residues | ||||
Sequence: SLREENEKRSHHKDHSDSESTSSDNSGKRRR | ||||||
Domain | 1146-1309 | JmjC | ||||
Sequence: KWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEW |
Sequence similarities
Belongs to the UTX family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,452
- Mass (Da)159,951
- Last updated2022-05-25 v1
- Checksum53427F58B48BDA79
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5ZM74 | A0A8I5ZM74_RAT | Kdm6a | 1400 | ||
A0A0G2K6D0 | A0A0G2K6D0_RAT | Kdm6a | 1316 | ||
A0A8I6GMA3 | A0A8I6GMA3_RAT | Kdm6a | 1373 | ||
A0A8I6ADI5 | A0A8I6ADI5_RAT | Kdm6a | 1321 | ||
A0A8I5ZXR3 | A0A8I5ZXR3_RAT | Kdm6a | 1418 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 486-515 | Polar residues | ||||
Sequence: RKRTSSPTKNTSDNWSGGNAVPHPPVQQQT | ||||||
Compositional bias | 564-610 | Polar residues | ||||
Sequence: TGVAQVRPTGIPNGPTADSSLPTNSASGQQPQLPLTRMPSVSQPGVQ | ||||||
Compositional bias | 861-913 | Polar residues | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEES | ||||||
Compositional bias | 968-988 | Pro residues | ||||
Sequence: KCPPPRPPSSPYPPLPKDKLN | ||||||
Compositional bias | 1097-1127 | Basic and acidic residues | ||||
Sequence: SLREENEKRSHHKDHSDSESTSSDNSGKRRR |
Keywords
- Technical term