A0A8I6A376 · A0A8I6A376_RAT
- ProteinCystic fibrosis transmembrane conductance regulator
- GeneCftr
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1499 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- chloride(in) = chloride(out)
- hydrogencarbonate(in) = hydrogencarbonate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | chloride channel complex | |
Cellular Component | early endosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | chloride channel activity | |
Molecular Function | isomerase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCystic fibrosis transmembrane conductance regulator
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I6A376
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Early endosome membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Recycling endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 98-117 | Helical | ||||
Sequence: ALRRCFVWRFVFYGVLLYLG | ||||||
Transmembrane | 145-169 | Helical | ||||
Sequence: IAIYLGIGLCLLFIVRTLLLHPAIF | ||||||
Transmembrane | 221-241 | Helical | ||||
Sequence: LALAHFIWIAPLQVVLLMGLL | ||||||
Transmembrane | 247-267 | Helical | ||||
Sequence: FSAFCGLGLLIVLVIFQAILG | ||||||
Transmembrane | 330-351 | Helical | ||||
Sequence: FFTSSAFFFSGFFVVFLSVLPY | ||||||
Transmembrane | 880-899 | Helical | ||||
Sequence: LFAVLIWCVLVFLVEVRMLG | ||||||
Transmembrane | 930-950 | Helical | ||||
Sequence: FYYIFYIYVGVADTLLALSLF | ||||||
Transmembrane | 1004-1026 | Helical | ||||
Sequence: FLPLTIFDFIQLLFIVVGAIIVV | ||||||
Transmembrane | 1032-1051 | Helical | ||||
Sequence: YIFLATVPGLAVFILLRAYF | ||||||
Transmembrane | 1123-1141 | Helical | ||||
Sequence: MIFVLFFIVVTFISILTTG | ||||||
Transmembrane | 1147-1165 | Helical | ||||
Sequence: TGIILTLAMNIMSTLQWAV |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 108-349 | ABC transmembrane type-1 | ||||
Sequence: VFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVL | ||||||
Domain | 438-672 | ABC transporter | ||||
Sequence: VQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMG | ||||||
Domain | 901-1176 | ABC transmembrane type-1 | ||||
Sequence: KWLLNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMR | ||||||
Domain | 1231-1462 | ABC transporter | ||||
Sequence: VKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSS | ||||||
Region | 1468-1499 | Disordered | ||||
Sequence: LFHGRHSSKQKPRTQITAVKEETEEEVQETRL | ||||||
Compositional bias | 1482-1499 | Basic and acidic residues | ||||
Sequence: QITAVKEETEEEVQETRL |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,499
- Mass (Da)170,041
- Last updated2022-05-25 v1
- ChecksumEFE91A86D1BE9FEB
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P34158 | CFTR_RAT | Cftr | 1476 | ||
A0A8I6AKE9 | A0A8I6AKE9_RAT | Cftr | 1662 | ||
A0A8I6AKF6 | A0A8I6AKF6_RAT | Cftr | 1446 | ||
A0A0G2K3B1 | A0A0G2K3B1_RAT | Cftr | 1665 | ||
A0A8I6AU15 | A0A8I6AU15_RAT | Cftr | 530 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1482-1499 | Basic and acidic residues | ||||
Sequence: QITAVKEETEEEVQETRL |
Keywords
- Technical term