A0A8I6A002 · A0A8I6A002_RAT

Function

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCAK-ERCC2 complex
Cellular Componentcytoplasm
Cellular ComponentMMXD complex
Cellular Componentnucleus
Cellular Componentspindle
Cellular Componenttranscription factor TFIID complex
Cellular Componenttranscription factor TFIIH core complex
Cellular Componenttranscription factor TFIIH holo complex
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functionprotein-macromolecule adaptor activity
Biological Processapoptotic process
Biological Processbone mineralization
Biological Processcentral nervous system myelin formation
Biological Processchromosome segregation
Biological Processdetermination of adult lifespan
Biological ProcessDNA repair
Biological Processembryonic cleavage
Biological Processembryonic organ development
Biological Processerythrocyte maturation
Biological Processextracellular matrix organization
Biological Processhair cell differentiation
Biological Processhair cycle process
Biological Processhair follicle maturation
Biological Processhematopoietic stem cell differentiation
Biological Processhematopoietic stem cell proliferation
Biological Processin utero embryonic development
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processintrinsic apoptotic signaling pathway by p53 class mediator
Biological Processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processmulticellular organism growth
Biological Processnucleotide-excision repair
Biological Processpositive regulation of mitotic recombination
Biological Processpost-embryonic development
Biological Processregulation of mitotic cell cycle phase transition
Biological Processregulation of transcription by RNA polymerase II
Biological Processresponse to hypoxia
Biological Processresponse to oxidative stress
Biological Processresponse to UV
Biological Processribosomal small subunit biogenesis
Biological Processskin development
Biological Processspinal cord development
Biological Processtranscription by RNA polymerase II
Biological Processtranscription elongation by RNA polymerase I
Biological Processtranscription initiation at RNA polymerase II promoter
Biological Processtranscription-coupled nucleotide-excision repair
Biological ProcessUV protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA 5'-3' helicase
  • EC number

Gene names

    • Name
      Ercc2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I6A002

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain290-434ATP-dependent helicase C-terminal

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    508
  • Mass (Da)
    57,987
  • Last updated
    2022-05-25 v1
  • Checksum
    BAFC706AF48EB282
MKTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3ZEG9D3ZEG9_RATErcc2760
A0A8I6AH26A0A8I6AH26_RATErcc2785

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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