A0A8I5ZYX2 · A0A8I5ZYX2_RAT
- ProteinC-1-tetrahydrofolate synthase, cytoplasmic
- GeneMthfd1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids902 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | formate-tetrahydrofolate ligase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-1-tetrahydrofolate synthase, cytoplasmic
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZYX2
Proteomes
Organism-specific databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-93 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | ||||
Sequence: SADDSNLYINVKLKAAQEIGIKATHIKLPRTSTESEVLKYVISLNEDATVHGFIVQLPLDSENSINTEAVINAIAPEKDVD | ||||||
Domain | 97-261 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | ||||
Sequence: SINAGKLARGDLKDCFIPCTPKGCLELIKETGVQIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTADLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGRKVVGDVAYDEAKEKASFITPVPGGVGPMTVAMLMQSTVESAQR |
Sequence similarities
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length902
- Mass (Da)97,187
- Last updated2022-05-25 v1
- ChecksumF7047F3368B51643
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P27653 | C1TC_RAT | Mthfd1 | 935 | ||
A0A8I5ZXQ9 | A0A8I5ZXQ9_RAT | Mthfd1 | 935 | ||
A0A8I6G8Q3 | A0A8I6G8Q3_RAT | Mthfd1 | 935 | ||
A0A8I6GID7 | A0A8I6GID7_RAT | Mthfd1 | 934 | ||
A0A8I5ZJK8 | A0A8I5ZJK8_RAT | Mthfd1 | 941 | ||
G3V6S5 | G3V6S5_RAT | Mthfd1 | 935 |
Keywords
- Technical term