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A0A8I5ZY41 · A0A8I5ZY41_RAT

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytosol
Cellular Componentdendritic spine
Cellular Componentexcitatory synapse
Cellular Componentgamma-tubulin complex
Cellular Componentpostsynaptic density
Cellular Componentsynaptic vesicle
Cellular Componentvoltage-gated calcium channel complex
Cellular ComponentZ disc
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functioncalcium channel regulator activity
Molecular FunctioncAMP binding
Molecular Functiongamma-tubulin binding
Molecular Functionmetal ion binding
Molecular Functiontransmembrane transporter binding
Biological ProcesscAMP catabolic process
Biological Processcellular response to epinephrine stimulus
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to xenobiotic stimulus
Biological Processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processnegative regulation of relaxation of cardiac muscle
Biological Processneutrophil chemotaxis
Biological Processneutrophil homeostasis
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of type II interferon production
Biological Processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Processregulation of cardiac muscle cell contraction
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      Pde4b

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZY41

Proteomes

Organism-specific databases

Family & Domains

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    736
  • Mass (Da)
    83,349
  • Last updated
    2022-05-25 v1
  • MD5 Checksum
    31C884F66D42A3CF360A1CF10C754940
MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVLHAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLEETDIDIATEDKSLIDT

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P14646PDE4B_RATPde4b736
F1M1T9F1M1T9_RATPde4b656
A0A8I6AT13A0A8I6AT13_RATPde4b721
A0A8L2Q3F0A0A8L2Q3F0_RATPde4b503
D3ZLB2D3ZLB2_RATPde4b659
A0A8I5ZX49A0A8I5ZX49_RATPde4b212

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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