A0A8I5ZWZ7 · A0A8I5ZWZ7_RAT

  • Protein
    RAF proto-oncogene serine/threonine-protein kinase
  • Gene
    Raf1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site.

166850100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site395ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componentplasma membrane
Cellular Componentpseudopodium
Molecular FunctionATP binding
Molecular Functionidentical protein binding
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionmetal ion binding
Molecular Functionsmall GTPase binding
Biological Processactivation of adenylate cyclase activity
Biological Processdeath-inducing signaling complex assembly
Biological ProcessERBB2-ERBB3 signaling pathway
Biological Processextrinsic apoptotic signaling pathway via death domain receptors
Biological Processface development
Biological Processinsulin receptor signaling pathway
Biological Processinsulin secretion involved in cellular response to glucose stimulus
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processintermediate filament cytoskeleton organization
Biological Processmyelination
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Processnegative regulation of protein-containing complex assembly
Biological Processneurotrophin TRK receptor signaling pathway
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein phosphorylation
Biological Processresponse to muscle stretch
Biological ProcessSchwann cell development
Biological Processsomatic stem cell population maintenance
Biological Processthymus development
Biological Processthyroid gland development
Biological Processtype B pancreatic cell proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RAF proto-oncogene serine/threonine-protein kinase
  • EC number
  • Alternative names
    • Proto-oncogene c-RAF
    • Raf-1

Gene names

    • Name
      Raf1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8I5ZWZ7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain56-131RBD
Domain138-184Phorbol-ester/DAG-type
Region217-272Disordered
Compositional bias222-272Polar residues
Compositional bias304-330Polar residues
Region304-354Disordered
Domain369-629Protein kinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    668
  • Mass (Da)
    75,189
  • Last updated
    2022-05-25 v1
  • Checksum
    AEA5C32D0D9DD06E
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTASDSGVPAPPSFTMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRACSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P11345RAF1_RATRaf1648
A0A8I6ALJ3A0A8I6ALJ3_RATRaf1608
A0A8L2Q6F4A0A8L2Q6F4_RATRaf1646

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias222-272Polar residues
Compositional bias304-330Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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