A0A8I5ZWZ7 · A0A8I5ZWZ7_RAT
- ProteinRAF proto-oncogene serine/threonine-protein kinase
- GeneRaf1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids668 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRAF proto-oncogene serine/threonine-protein kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8I5ZWZ7
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-131 | RBD | ||||
Sequence: NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFL | ||||||
Domain | 138-184 | Phorbol-ester/DAG-type | ||||
Sequence: THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC | ||||||
Region | 217-272 | Disordered | ||||
Sequence: MRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV | ||||||
Compositional bias | 222-272 | Polar residues | ||||
Sequence: SRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV | ||||||
Compositional bias | 304-330 | Polar residues | ||||
Sequence: HSESASPSALSSSPNNLSPTGWSQPKT | ||||||
Region | 304-354 | Disordered | ||||
Sequence: HSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRG | ||||||
Domain | 369-629 | Protein kinase | ||||
Sequence: VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length668
- Mass (Da)75,189
- Last updated2022-05-25 v1
- ChecksumAEA5C32D0D9DD06E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P11345 | RAF1_RAT | Raf1 | 648 | ||
A0A8I6ALJ3 | A0A8I6ALJ3_RAT | Raf1 | 608 | ||
A0A8L2Q6F4 | A0A8L2Q6F4_RAT | Raf1 | 646 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 222-272 | Polar residues | ||||
Sequence: SRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV | ||||||
Compositional bias | 304-330 | Polar residues | ||||
Sequence: HSESASPSALSSSPNNLSPTGWSQPKT |
Keywords
- Technical term